Note: The odds for the Cleveland Browns are off the board due to uncertainty with Deshaun Watson.
| Team | Opening Odds |
| Arizona Cardinals | Over 9.5 (+135) |
| Under 9.5 (-165) | |
| Atlanta Falcons | Over 4.5 (+100) |
| Under 4.5 (-120) | |
| Baltimore Ravens | Over 9.5 (-125) |
| Under 9.5 (+105) | |
| Buffalo Bills | Over 11.5 (-120) |
| Under 11.5 (+100) | |
| Carolina Panthers | Over 5.5 (-120) |
| Under 5.5 (+100) | |
| Chicago Bears | Over 6.5 (-140) |
| Under 6.5 (+115) | |
| Cincinnati Bengals | Over 9.5 (-110) |
| Under 9.5 (-110) | |
| Cleveland Browns | Off the board |
| Dallas Cowboys | Over 10.5 (-110) |
| Under 10.5 (-110) | |
| Denver Broncos | Over 10.5 (+130) |
| Under 10.5 (-160) | |
| Detroit Lions | Over 6.5 (+130) |
| Under 6.5 (-160) | |
| Green Bay Packers | Over 10.5 (-140) |
| Under 10.5 (+115) | |
| Houston Texans | Over 4.5 (-105) |
| Under 4.5 (-115) | |
| Indianapolis Colts | Over 9.5 (-125) |
| Under 9.5 (+105) | |
| Jacksonville Jaguars | Over 6.5 (+105) |
| Under 6.5 (-125) | |
| Kansas City Chiefs | Over 10.5 (-110) |
| Under 10.5 (-110) | |
| Las Vegas Raiders | Over 8.5 (-110) |
| Under 8.5 (-110) | |
| Los Angeles Chargers | Over 10.5 (+120) |
| Under 10.5 (-145) | |
| Los Angeles Rams | Over 10.5 (-105) |
| Under 10.5 (-115) | |
| Miami Dolphins | Over 8.5 (-120) |
| Under 8.5 (+100) | |
| Minnesota Vikings | Over 8.5 (-130) |
| Under 8.5 (+110) | |
| New England Patriots | Over 8.5 (-120) |
| Under 8.5 (+100) | |
| New Orleans Saints | Over 8.5 (+120) |
| Under 8.5 (-140) | |
| New York Giants | Over 7.5 (+110) |
| Under 7.5 (-130) | |
| New York Jets | Over 5.5 (-110) |
| Under 5.5 (-110) | |
| Philadelphia Eagles | Over 8.5 (-115) |
| Under 8.5 (-105) | |
| Pittsburgh Steelers | Over 7.5 (-120) |
| Under 7.5 (+100) | |
| San Francisco 49ers | Over 9.5 (-140) |
| Under 9.5 (+120) | |
| Seattle Seahawks | Over 5.5 (-130) |
| Under 5.5 (+110) | |
| Tampa Bay Buccaneers | Over 11.5 (-110) |
| Under 11.5 (-110) | |
| Tennessee Titans | Over 9.5 (+100) |
| Under 9.5 (-120) | |
| Washington Commanders | Over 7.5 (-110) |
| Under 7.5 (-110) | |
| Sportsbook Data Insights by BetMGM | |
|
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| Team | Opening Odds | ||
| Arizona Cardinals | Make -110 | ||
| Miss -110 | |||
| Atlanta Falcons | Make +500 | ||
| Miss -700 | |||
| Baltimore Ravens | Make -130 | ||
| Miss +105 | |||
| Buffalo Bills | Make -600 | ||
| Miss +400 | |||
| Carolina Panthers | Make +500 | ||
| Miss -700 | |||
| Chicago Bears | Make +300 | ||
| Miss -400 | |||
| Cincinnati Bengals | Make -135 | ||
| Miss +110 | |||
| Cleveland Browns | Off the board | ||
| Dallas Cowboys | Make -275 | ||
| Miss +220 | |||
| Denver Broncos | Make -150 | ||
| Miss +125 | |||
| Detroit Lions | Make +500 | ||
| Miss -700 | |||
| Green Bay Packers | Make -500 | ||
| Miss +375 | |||
| Houston Texans | Make +1000 | ||
| Miss -2000 | |||
| Indianapolis Colts | Make -165 | ||
| Miss +135 | |||
| Jacksonville Jaguars | Make +400 | ||
| Miss -550 | |||
| Kansas City Chiefs | Make -225 | ||
| Miss +180 | |||
| Las Vegas Raiders | Make +160 | ||
| Miss -200 | |||
| Los Angeles Chargers | Make -150 | ||
| Miss +125 | |||
| Los Angeles Rams | Make -250 | ||
| Miss +200 | |||
| Miami Dolphins | Make +135 | ||
| Miss -165 | |||
| Minnesota Vikings | Make +100 | ||
| Miss -120 | |||
| New England Patriots | Make +135 | ||
| Miss -165 | |||
| New Orleans Saints | Make +160 | ||
| Miss -200 | |||
| New York Giants | Make +225 | ||
| Miss -275 | |||
| New York Jets | Make +900 | ||
| Miss -1600 | |||
| Philadelphia Eagles | Make +120 | ||
| Miss -145 | |||
| Pittsburgh Steelers | Make +300 | ||
| Miss -400 | |||
| San Francisco 49ers | Make -225 | ||
| Miss +180 | |||
| Seattle Seahawks | Make +350 | ||
| Miss -500 | |||
| Tampa Bay Buccaneers | Make -600 | ||
| Miss +425 | |||
| Tennessee Titans | Make -125 | ||
| Miss +105 | |||
| Washington Commanders | Make +195 | ||
| Miss -250 | |||
| Sportsbook Data Insights by BetMGM | |||