| New York Jets at Detroit Lions - Week 1 - Monday, September 10, 2018 7:10 PM | ||||
| 479 New York Jets | +7½ -140 | +250 | Over 44½ -110 | |
| 480 Detroit Lions | -7½ +120 | -300 | Under 44½ -110 | |
| Los Angeles Rams at Oakland Raiders - Week 1 - Monday, September 10, 2018 10:20 PM | ||||
| 481 Los Angeles Rams | -4½ -110 | -230 | Over 47½ -110 | |
| 482 Oakland Raiders | +4½ -110 | +190 | Under 47½ -110 | |