These teams are getting very familiar with each other as this is their third meeting in a year. The Niners won both meetings easily last year including in the playoffs when Kaepernick set an NFL quarterback rushing record for ANY game (regular season or playoffs) with 181 to go along with 263 passing yards and accounting for four touchdowns. Some of the characters have changed, such as Michael Crabtree out and Anquan Boldin in for 49ers and the Packers actually having a running game now with Eddie Lacy, the the deciding factor here should again be Green Bay's inability to stop the read option.
