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Titans vs. Bills Same Game Parlay Picks: Great Value on WR Props

Top NFL same-game parlay picks for the first game of the Week 2 Monday Night Football doubleheader between the Titans and Bills.

Brenden Schaeffer

Last Updated: October 8, 2025 11:12 AM EDT • 4 minute read

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After a disappointing Week 1 loss, life doesn’t get any easier for the Tennessee Titans as they head to Buffalo on Monday night. Here are our Week 2 Titans-Bills same-game parlay picks.

Buffalo ran roughshod over the Los Angeles Rams in Week 1. Now Bills Mafia gets its first chance of the year to support Josh Allen and Co. But will the Bills ensure there won't be a letdown in their home opener?

Here are my same-game parlay picks for the Week 2 Monday night matchup between the Titans and Bills (odds via DraftKings Sportsbook; pick confidence based on a 1-to-5-star scale).

Titans vs. Bills Same Game Parlay Picks

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Titans vs. Bills Same Game Parlay Predictions

Titans +10.5 (-125) ★★★

To lose to the New York Giants at home in Week 1, the Titans had to have played some bad football. And they did, as Mike Vrabel’s offense didn’t look prepared to move forward with life after star receiver A.J. Brown. But Vrabel is one of the more capable game-planners in the NFL and I expect adjustments from this coaching staff after last week’s disappointment.

The Bills are flying high after dousing the Rams, but there are reasons to hesitate in assuming things will come so easily for Buffalo again offensively this week. Tennessee won this game a year ago in Nashville, 34-31. Though this is a different Titans team, Ryan Tannehill and Derrick Henry are still here. They’ll make the adjustments from Week 1 to keep this game competitive.

Getting the hook with DraftKings to +10.5 compared to +10 at FanDuel is enough to convince me to use DK for the parlay, despite a slight combined odds advantage with FD.

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Diggs Over 79.5 receiving yards (-110) ★★★★★

Stefon Diggs was a featured staple in the Buffalo offense in the opening win over the Rams, torching Jalen Ramsey and the rest of the Rams secondary for 122 yards and a touchdown. Diggs earned nine targets and hauled in eight catches as a go-to weapon for Allen. This week, Diggs might be even more integral to the Bills' offense than he was in Week 1.

Fellow wideout Gabe Davis suffered a non-contact ankle injury in practice Saturday that could keep him out of this game, or limit him at the very least. The Bills could turn to Isaiah McKenzie and others to fill the void, but the alternative concept makes sense, too: Simply hyper-target one of the best wide receivers in the NFL.

Diggs needs to secure three additional receiving yards on this line of 79.5 relative to the most similar offering at FanDuel (76.5), but as I’m choosing between Diggs and the hook on the point spread, I value the hook for the Titans more significantly.

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Burks anytime touchdown scorer (+450) ★★★★

Week 1 made it clear that the Titans need answers in the passing game after Brown’s departure. Veteran receiver Robert Woods entered the season as an obvious candidate to soak up opportunities, but he didn’t make much of an impact in Week 1. Rookie Treylon Burks, though, showed some flashes that could suggest more work moving forward.

Burks’ 55 yards receiving ranked sixth in Titans/Oilers history for a first-year player in Week 1. Though Woods enters Monday with the revenge-game narrative against the Bills, Burks is the explosive athlete whose contributions could help keep the Titans in this game.

It’s time to unleash the rookie out of Arkansas, and in a game in which the Titans will likely need to pass to keep pace, I like their most explosive receiving athlete to find the end zone in Week 2.

Combined odds: Titans +10.5 (-125) + Diggs Over 79.5 receiving yards (+105) + Burks anytime touchdown scorer (+450) = +1100

Where to Bet on Titans-Bills Picks

Here are our top-rated sportsbooks:

FanDuel Sportsbook
Caesars Sportsbook
DraftKings Sportsbook
PointsBet
BetMGM

SEE ALSO: All picks, odds, and sports betting news. Be sure to check out SportsbookReview.com’s community forums and betting tools.

Titans-Bills picks made 9/18/2022 at 3:45 p.m. ET.

Written by:
Brenden Schaeffer

Brenden has covered the St. Louis Cardinals as a credentialed baseball writer for KMOV-TV since 2016. His sports writing has appeared in outlets including the Austin American-Statesman and Columbia Daily Tribune. Since 2021, Brenden has co-hosted 'The Big Show' during the afternoon drive for KTGR, the ESPN radio affiliate in Columbia, MO. He has appeared on radio stations around the country, including KMOX, and hosts a daily St. Louis Cardinals podcast. In the sports betting content space, Brenden has covered the NFL, college football, NBA, and college basketball for outlets including SBR since 2019. For his football handicapping, Brenden looks to target player prop markets using his NFL experience, as well as sharp underdog lines in college football. Brenden looks to reference FanDuel for his sports betting articles because of its consistently competitive odds on parlays. FanDuel's boost offerings are also customer-friendly, and its odds on the NFL Same Game Parlay articles he's written for SBR have historically been consistently competitive compared to other books.