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Geno Smith of the Seattle Seahawks passes against the New York Giants at Lumen Field on Oct. 30, 2022 in Seattle, Washington.
Geno Smith of the Seattle Seahawks passes against the New York Giants at Lumen Field on Oct. 30, 2022 in Seattle, Washington. Photo by Lindsey Wasson/Getty Images via AFP.

The Seattle Seahawks beat the Arizona Cardinals 19-9 in Week 6, and they'll look to sweep their NFC West rivals for the sixth time in 20 years. Read on for our Seahawks-Cardinals picks.

After a 27-13 win over the New York Giants last week, Seattle is on a three-game winning streak, with all of those victories coming by double digits. The Seahawks are the only NFL team with three straight double-digit wins this year. 

They’re 2-point underdogs this weekend, so can head coach Pete Carroll’s men cause an upset in the desert? 

Here are our Seahawks-Cardinals NFL Week 9 picks (odds via Caesars Sportsbook and PointsBet; pick confidence based on a 1-to-5-star scale).

Check out our NFL best bets and all of our top picks for Week 9!

Seahawks vs. Cardinals Game Info

  • Date: Sunday, Nov. 6, 4:05 p.m. ET
  • TV: Fox
  • Location: State Farm Stadium, Glendale, AZ
  • Weather: Indoors

Seahawks vs. Cardinals Odds

Seahawks vs. Cardinals Odds Analysis

The Cardinals opened as 3.5-point favorites, but that line has moved as bettors back Seattle. The Cards are now down to -1.5 favorites, with 62% of the cash and 65% of the tickets going toward the Seahawks. 

The total has also shifted throughout the week. On Tuesday it moved from 50 to 50.5, but it appears to have stabilized at 49.5. There's two-way action, with 61% of the cash on the Under, while 71% of the tickets are on the Over.

Seahawks vs. Cardinals Picks

  • Spread: Seahawks +2 (-107 via PointsBet) ★★★★★
  • Over/Under: Over 49.5 (-107 via PointsBet) ★★★★
  • Prop pick: Will Dissly anytime touchdown scorer (+335 via Caesars) ★★★

Seahawks vs. Cardinals ATS Pick

Seahawks +2 (-107) ★★★★★

The Seahawks are one of the league's biggest surprises this season. In the post-Russell Wilson era, Pete Carroll has his team sitting at 5-3, top of the NFC West. They head to Arizona to take on a Cardinals team that’s last in the division at 3-5.

Head coach Kliff Kingsbury took over the Cardinals in 2019, and throughout his tenure they’re 5-11 ATS as home favorites. In its last 20 divisional home games, Arizona is 5-14-1 and has been outscored by 150 points. Seahawks quarterback Geno Smith leads NFL QBs this season with a 72.7% completion percentage. 

The Seahawks have the better coach and are on the in-form teams in the league. The two points being laid are a gift. 

Seahawks vs. Cardinals O/U Pick

Over 49.5 (-107) ★★★★

The Seahawks have 14 touchdowns of 20 or more yards this season, four more than any other NFL team. Their four rushing TDs of 20+ yards are also the NFL's most. The Cardinals gave up the second most points this season and rank last against red zone attempts and red zone TDs.

Arizona has wide receiver DeAndre Hopkins, unlike their previous Week 6 matchup with Seattle. Hopkins had 22 catches in his two games for the Cards this season and 12 receptions in Arizona’s 34-26 loss to Minnesota last week. He hopes to become the second player in the Super Bowl era to start a season with three straight games with 10+ catches (Michael Thomas – 2018). 

The Seahawks have given up the league's third most yards this year and are bottom four in rushing yards and rushing attempts allowed. Arizona QB Kyler Murray rushed for 100 yards against Seattle on October 16. The Seahawks averaged 28 points per game during their three-game winning streak, and the Cardinals have enough firepower to make this a contest. They’ll need to score points to avoid going 0-3 in the division and three games behind the leaders.  

Seahawks vs. Cardinals Prop Pick

Dissly anytime touchdown scorer (+335) ★★★

No team gives up more touchdowns to tight ends this season than the Cardinals (7). Only the Seahawks allow more yards to the position. Arizona also gives up a league-high average of seven receptions per game to tight ends in 2022. Seattle tight end Will Dissly caught three touchdown passes this season, which is joint third highest in the NFL. Dissly will be a key red zone target against the league’s worst D inside the 20. These are favorable odds are for this matchup. 

Where to Bet on Seahawks vs. Cardinals Picks

Here are our top-rated sportsbooks:

Seahawks-Cardinals picks made 11/3/2022 at 6:00 p.m. ET