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Deebo Samuel of the San Francisco 49ers reacts after scoring a touchdown in the second quarter against the Los Angeles Rams.
Deebo Samuel of the San Francisco 49ers reacts after scoring a touchdown in the second quarter against the Los Angeles Rams. Photo by Christian Petersen/Getty Images via AFP.

The Los Angeles Rams travel to the Bay Area to take on the San Francisco 49ers for Monday Night Football. Check out our Week 4 Monday Night Football Rams-49ers prop picks.

A heated rivalry will be renewed on Monday night as the Rams take the short hop north to meet the 49ers.

Once again, Jimmy Garopplo will lead the San Francisco offense in this matchup. These two teams met on Monday night in Week 10 last season, and the 49ers came out on top of that one, 31-10.

Here are our best picks and predictions for the Week 4 Monday Night Football game between the Rams and 49ers (odds via BetMGM and DraftKings Sportsbook).

Top Monday Night Football Prop Picks

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Top MNF Prop Predictions for Week 4

Wilson longest rush Over 12.5 yards (-125)

Jeff Wilson has topped this number in both of his games since becoming the 49ers’ lead running back. In Week 2 against the Seattle Seahawks, he charged ahead for a 16-yard carry. Last week, he ripped off a 37-yarder against the Denver Broncos. In his career, he has 13 games with a rush Over this number.

So far, only Devin Singletary has been able to produce a carry of at least 13 yards against the Rams this season. However, both Cordarrelle Patterson and James Conner reached 10 yards on a single carry in their games against Los Angeles.

Check out the latest comprehensive and most trusted Sportsbook Reviews by SBR.

Samuel -1.5 receptions vs. Robinson (+100)

Deebo Samuel has two games with five receptions so far this season. He’s also been the 49ers' most targeted receiver in two games this year. Samuel is averaging 5.5 receptions per game against the Rams. This includes an 11-catch performance in a prime-time game during the 2020 season.

Allen Robinson enters Monday night with just seven receptions all season. His highest output was a four-catch game in Week 2 against the Atlanta Falcons. He is at a disadvantage in this particular matchup given the fact that he has been targeted only 12 times this season. That puts him fourth on the team behind even Ben Skowronek.

Floyd Over 3.5 total tackles (+135)

Last week was the first of the season in which Leonard Floyd crossed this mark. The veteran linebacker secured four total tackles against the Atlanta Falcons. Last season, Floyd had only eight games in which he did not reach this total. Additionally, he has had at least four combined tackles in three of his six career games against San Francisco.

The 49ers have the fifth most rushing attempts so far this season. As such, eight different linebackers have accumulated at least four tackles over San Francisco’s first three games. All told, the position accounts for 76 total tackles vs. the 49ers.

Where to Bet on Rams-49ers Picks

Rams-49ers prop picks made 10/2/2022 at 12:07 a.m. ET