Ole Miss vs. Oklahoma Prediction: Week 11 Odds, Picks & Best Bet (Nov. 14)
Last Updated: November 13, 2026 3:15 PM EST • 3 minute read X Social Google News Link
A late-afternoon SEC tilt between opponents coming off much different results in Week 10 forms my Ole Miss vs. Oklahoma prediction.
No. 19 Ole Miss, led by QB Trinidad Chambliss, will attempt to overcome the loss of RB Kewan Lacy against a stout Oklahoma defense Saturday. The Sooners are a 1.5-point betting favorite, with kickoff from Memorial Stadium in Norman, Okla., set for 4:15 p.m. ET (SEC Network).
Ole Miss vs. Oklahoma picks & predictions
See all of our experts' college football picks for Week 11 based on the latest college football odds.
| Pick | Odds | Bet size |
|---|---|---|
| Ole Miss +1.5 | -115 via FanDuel | 1.15 units to profit 1 unit |
| Under 49.5 | -110 via BetMGM | 2.2 units to profit 2 units |
Picks submitted: Nov. 13 at 2 p.m. ET. Odds subject to change.
Total wagered: 3.35 units | Profit if all picks win: 3 units
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Ole Miss vs. Oklahoma prediction & best bet
Check out all of our college football predictions for more analysis across this week's slate.
Under 49.5 (-110 via BetMGM)
Oklahoma found its top defensive form on the road against Florida in Week 10, holding the Gators to 7 points in a huge 23-7 win to improve to .500 against SEC opponents. Sooners QB John Mateer and the Sooners' offense will face a soft Ole Miss defense, ranked 10th in the SEC for points allowed per game (26.0) this season.
The absence of Lacy from the Ole Miss offense is going to be a real issue for Chambliss in this game. Weather could turn ugly and 15 mph wind will challenge passes, so an Oklahoma defense that's held opponents to 3.6 YPC, while forcing 7 turnovers in its past three outings, will be a tough assignment for the Rebels' high-paid signal-caller.
Ole Miss' defense finally has a soft matchup in return. The Sooners have only scored 1 rushing touchdown since Week 1, so the Rebels have a chance to bounce back after giving up 6.1 YPC to No. 1 Georgia last weekend.
This game is going to be gritty and the best offense on the field is short-handed. Plus, bad weather could create long, empty possessions.
Bet Under 49.5 at -110 odds on BetMGM.
📡 SBR Edge: Rebel Run-less
Ole Miss has only logged two rushing touchdowns in its last three appearances against ranked SEC opponents.
Ole Miss defense shows up to beat Oklahoma in Norman
Chambliss will use his legs to extend plays and make up for Lacy's absence in the backfield against Oklahoma. The Sooners' 15th-ranked scoring offense in the SEC, averaging 22.1 points per game, doesn't have the same high-octane, explosive production with Mateer, even compared to a short-handed Chambliss.
Ole Miss defense takes advantage of a bottom-tier offense. The Rebels hold Oklahoma to 20 points in Norman, bouncing back after bad performances against top-10 teams like Texas and Georgia.
Play to: Under 48.5
Score prediction: Ole Miss 23, Oklahoma 20
Live Ole Miss vs. Oklahoma odds
See the latest odds movement and more on our Ole Miss vs. Oklahoma matchup page.
Ole Miss vs. Oklahoma opening odds
- Moneyline: Ole Miss -134 | Oklahoma +112
- Spread: Ole Miss -2.5 (-115) | Oklahoma +2.5 (-105)
- Over/Under: Over 49.5 (-110) | Under 49.5 (-110)
Ole Miss vs. Oklahoma weather
The forecast at Memorial Stadium in Norman, Okla., for Saturday's opening kickoff calls for 54 degrees with 15 mph wind and a 9 percent probability of precipitation. Overcast skies and windy conditions, with a potential for rain, will be a major factor in this game.
Latest Ole Miss vs. Oklahoma injuries
Ole Miss:
- RB Kewan Lacy - Out
Oklahoma:
- None
How to watch Ole Miss vs. Oklahoma: Week 11
- Date: Saturday, Nov. 14
- Kickoff: 4:15 p.m. ET
- Location: Memorial Stadium (Norman, Okla.)
- TV/Streaming: SEC Network, Fubo
Matt MacKay X social