College Football Week 7 AI Predictions: ATS Picks & Score Projections for Top 25 Games
With conference races heating up, our college football AI predictions for Week 7 feature projected scores and against-the-spread picks for the 25 most intriguing games on the schedule.
The slate is headlined by No. 4 Ohio State visiting unbeaten No. 5 Indiana, while No. 2 Notre Dame travels to face No. 8 BYU. Other major matchups include No. 6 Alabama at No. 14 Tennessee, No. 13 Missouri at No. 9 Ole Miss, and No. 18 Oklahoma State visiting No. 20 Houston.
The AI model weighs recent performance, advanced metrics, injuries, roster strength, matchup advantages, home-field edge, and current market movement. All ATS picks below use Kalshi's college football spread markets as of Thursday, Oct. 15.
Follow all of SBR's college football picks throughout the season and check the latest college football odds before kickoff.
College Football Week 7 AI predictions
| Date | Kickoff (ET) | Prediction | ATS pick |
|---|---|---|---|
| Fri., Oct. 16 | 7:30 p.m. | Memphis 31, Tulane 20 | Memphis -6.5 |
| Fri., Oct. 16 | 8 p.m. | Purdue 30, Washington 20 | Purdue -3.5 |
| Sat., Oct. 17 | Noon | Ohio State 30, Indiana 24 | Ohio State -3.5 |
| Sat., Oct. 17 | Noon | Texas 31, Florida 17 | Texas -10.5 |
| Sat., Oct. 17 | Noon | LSU 37, Mississippi State 20 | LSU -13.5 |
| Sat., Oct. 17 | Noon | SMU 34, Virginia 20 | SMU -9.5 |
| Sat., Oct. 17 | Noon | Kansas State 27, Kansas 24 | Kansas +6.5 |
| Sat., Oct. 17 | Noon | Boston College 24, Pitt 21 | Boston College +6.5 |
| Sat., Oct. 17 | Noon | Cincinnati 34, West Virginia 31 | Cincinnati +1.5 |
| Sat., Oct. 17 | 3:30 p.m. | Michigan 27, Penn State 17 | Michigan -6.5 |
| Sat., Oct. 17 | 3:30 p.m. | Georgia 38, Auburn 13 | Georgia -20.5 |
| Sat., Oct. 17 | 3:30 p.m. | Ole Miss 34, Missouri 27 | Ole Miss -5.5 |
| Sat., Oct. 17 | 3:30 p.m. | Alabama 34, Tennessee 23 | Alabama -9.5 |
| Sat., Oct. 17 | 3:30 p.m. | Duke 27, North Carolina 24 | North Carolina +3.5 |
| Sat., Oct. 17 | 3:30 p.m. | Virginia Tech 34, Georgia Tech 20 | Virginia Tech -10.5 |
| Sat., Oct. 17 | 3:30 p.m. | Texas Tech 35, Arizona State 17 | Texas Tech -7.5 |
| Sat., Oct. 17 | 7 p.m. | Miami 41, Florida State 17 | Miami -21.5 |
| Sat., Oct. 17 | 7 p.m. | Vanderbilt 30, Arkansas 20 | Vanderbilt -6.5 |
| Sat., Oct. 17 | 7:30 p.m. | Houston 31, Oklahoma State 28 | Oklahoma State +3.5 |
| Sat., Oct. 17 | 7:30 p.m. | Notre Dame 34, BYU 20 | Notre Dame -10.5 |
| Sat., Oct. 17 | 7:30 p.m. | Oklahoma 27, Kentucky 24 | Kentucky +6.5 |
| Sat., Oct. 17 | 7:30 p.m. | UCLA 27, Wisconsin 20 | UCLA -1.5 |
| Sat., Oct. 17 | 7:30 p.m. | Louisville 34, Syracuse 17 | Louisville -14.5 |
| Sat., Oct. 17 | 10:15 p.m. | Utah 35, Colorado 17 | Utah -8.5 |
| Sat., Oct. 17 | 11 p.m. | Oregon 34, Nebraska 20 | Oregon -6.5 |
Memphis vs Tulane AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Memphis | 7 | 10 | 7 | 7 | 31 |
| Tulane | 3 | 7 | 3 | 7 | 20 |
Memphis has been the more consistent team through the first half of the season and brings a clear offensive advantage into New Orleans. Tulane should keep this competitive early at home, but Memphis has enough explosiveness to create separation once the game opens up.
ATS pick: Memphis -6.5
Washington vs Purdue AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Washington | 3 | 7 | 3 | 7 | 20 |
| Purdue | 7 | 10 | 6 | 7 | 30 |
Washington has struggled to find consistency away from home and now faces another difficult Big Ten road environment. Purdue isn't an overwhelming favorite, but the Boilermakers should be able to generate enough sustained offense to gradually create a two-possession advantage.
ATS pick: Purdue -3.5
Ohio State vs Indiana AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Ohio State | 7 | 10 | 6 | 7 | 30 |
| Indiana | 7 | 7 | 3 | 7 | 24 |
Indiana's long winning streak makes this the marquee matchup of Week 7, and the Hoosiers have earned the opportunity to host a game of this magnitude. Ohio State still owns the deeper roster and more explosive passing attack, giving the Buckeyes a slight edge in a competitive four-quarter matchup.
ATS pick: Ohio State -3.5
Florida vs Texas AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Florida | 3 | 7 | 0 | 7 | 17 |
| Texas | 7 | 10 | 7 | 7 | 31 |
Texas needs a response after its first loss of the season and returns home for a favorable bounce-back opportunity. Florida remains talented enough to create problems defensively, but the Longhorns should be more efficient offensively and eventually establish control in the second half.
ATS pick: Texas -10.5
Mississippi State vs LSU AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Mississippi State | 3 | 7 | 3 | 7 | 20 |
| LSU | 10 | 10 | 10 | 7 | 37 |
Both teams enter ranked, but LSU's home-field advantage and higher offensive ceiling create a difficult matchup for Mississippi State. The Bulldogs can generate enough offense to avoid being completely overwhelmed, though LSU should produce consistent scoring opportunities and pull away after halftime.
ATS pick: LSU -13.5
Virginia vs SMU AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Virginia | 3 | 7 | 3 | 7 | 20 |
| SMU | 7 | 10 | 10 | 7 | 34 |
SMU has worked its way back into the AP Top 25 and gets an important ACC matchup at home. Virginia has been competitive enough to avoid overlooking, but the Mustangs have the more dynamic offense and should create enough explosive plays to win comfortably.
ATS pick: SMU -9.5
Kansas vs Kansas State AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Kansas | 7 | 7 | 3 | 7 | 24 |
| Kansas State | 7 | 10 | 3 | 7 | 27 |
The Sunflower Showdown should be much tighter than the records might suggest. Kansas State deserves to be favored at home, but Kansas has enough offensive upside to keep this within one possession. A field-goal game feels more realistic than a comfortable Wildcats victory.
ATS pick: Kansas +6.5
Pitt vs Boston College AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Pitt | 7 | 7 | 0 | 7 | 21 |
| Boston College | 3 | 7 | 7 | 7 | 24 |
Pitt has been one of the bigger surprises this season, but its quarterback situation has changed the outlook of the offense. Boston College gets the Panthers at home and has a realistic opportunity to turn this into a low-scoring game where one late possession determines the result.
ATS pick: Boston College +6.5
Cincinnati vs West Virginia AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Cincinnati | 7 | 10 | 10 | 7 | 34 |
| West Virginia | 7 | 10 | 7 | 7 | 31 |
There isn't much separating these Big 12 teams, making the short home number difficult to trust with West Virginia. Cincinnati has enough offensive playmaking ability to match the Mountaineers in a higher-scoring matchup and has a legitimate path to winning outright.
ATS pick: Cincinnati +1.5
Penn State vs Michigan AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Penn State | 3 | 7 | 0 | 7 | 17 |
| Michigan | 7 | 10 | 3 | 7 | 27 |
Penn State continues to struggle for offensive consistency, and a trip to Michigan creates another difficult assignment. Neither offense has been completely trustworthy, but Michigan has the more favorable matchup at home and should be able to control the line of scrimmage.
ATS pick: Michigan -6.5
Auburn vs Georgia AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Auburn | 3 | 3 | 0 | 7 | 13 |
| Georgia | 10 | 14 | 7 | 7 | 38 |
Georgia returns home after another statement victory and should have a major advantage in the trenches against Auburn. Rivalry games can be unpredictable, but the Bulldogs' defense should prevent Auburn from sustaining enough drives to keep this competitive for four quarters.
ATS pick: Georgia -20.5
Missouri vs Ole Miss AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Missouri | 7 | 7 | 6 | 7 | 27 |
| Ole Miss | 7 | 10 | 10 | 7 | 34 |
Missouri enters with momentum and a defense capable of making Ole Miss work for points, but Oxford remains a difficult road assignment. The Rebels have the more explosive offense and should be able to create enough chunk plays to build a second-half advantage.
ATS pick: Ole Miss -5.5
Alabama vs Tennessee AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Alabama | 7 | 10 | 10 | 7 | 34 |
| Tennessee | 3 | 7 | 6 | 7 | 23 |
Alabama is coming off its first loss, but the Crimson Tide remain one of the deeper teams in the country. Tennessee will have a significant home-field edge, though Alabama's ability to pressure the quarterback and generate explosive offense should produce a strong response.
ATS pick: Alabama -9.5
North Carolina vs Duke AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| North Carolina | 7 | 7 | 3 | 7 | 24 |
| Duke | 7 | 10 | 3 | 7 | 27 |
Duke has been the more consistent team this season, but rivalry games between these programs tend to produce additional volatility. North Carolina has enough offensive talent to keep this within one possession even if Duke ultimately protects home field.
ATS pick: North Carolina +3.5
Georgia Tech vs Virginia Tech AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Georgia Tech | 3 | 7 | 3 | 7 | 20 |
| Virginia Tech | 7 | 10 | 10 | 7 | 34 |
Virginia Tech has been much more dependable at home and owns the defensive advantage in this ACC matchup. Georgia Tech can produce explosive plays, but the Hokies should create enough negative plays and favorable field position to eventually build a comfortable lead.
ATS pick: Virginia Tech -10.5
Arizona State vs Texas Tech AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Arizona State | 3 | 7 | 0 | 7 | 17 |
| Texas Tech | 7 | 14 | 7 | 7 | 35 |
Texas Tech remains unbeaten and has consistently shown the ability to create separation when its offense finds rhythm. Arizona State faces a difficult road assignment against a Red Raiders team with advantages in both overall depth and explosive-play potential.
ATS pick: Texas Tech -7.5
Florida State vs Miami AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Florida State | 3 | 7 | 0 | 7 | 17 |
| Miami | 10 | 14 | 10 | 7 | 41 |
The rivalry element makes Florida State dangerous, but Miami has been operating at a significantly higher level through the opening half of the season. The Hurricanes should be able to create pressure defensively while generating enough explosive offense to make this one-sided.
ATS pick: Miami -21.5
Arkansas vs Vanderbilt AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Arkansas | 3 | 7 | 3 | 7 | 20 |
| Vanderbilt | 7 | 10 | 6 | 7 | 30 |
Vanderbilt gets a more manageable assignment after facing one of the SEC's strongest teams last week. Arkansas has struggled to find consistency on both sides of the ball, while the Commodores should have enough balance to create a two-score margin at home.
ATS pick: Vanderbilt -6.5
Oklahoma State vs Houston AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Oklahoma State | 7 | 7 | 7 | 7 | 28 |
| Houston | 7 | 10 | 7 | 7 | 31 |
This ranked Big 12 matchup is one of the most difficult games on the slate to separate. Houston gets the home-field edge and has played increasingly well, but Oklahoma State has enough offensive firepower to keep the game competitive deep into the fourth quarter.
ATS pick: Oklahoma State +3.5
Notre Dame vs BYU AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Notre Dame | 7 | 10 | 10 | 7 | 34 |
| BYU | 3 | 7 | 3 | 7 | 20 |
BYU remains unbeaten and gets one of its biggest home games in years, but Notre Dame presents a different level of physicality. The Irish should have advantages at the line of scrimmage on both sides and enough offensive balance to pull away in the second half.
ATS pick: Notre Dame -10.5
Kentucky vs Oklahoma AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Kentucky | 7 | 7 | 3 | 7 | 24 |
| Oklahoma | 7 | 10 | 3 | 7 | 27 |
Oklahoma enters with renewed confidence but now faces a Kentucky team that has repeatedly shown an ability to stay competitive in tight SEC games. Home field gives the Sooners a slight edge, but laying nearly a touchdown is too aggressive for a matchup projected to remain close.
ATS pick: Kentucky +6.5
Wisconsin vs UCLA AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Wisconsin | 3 | 7 | 3 | 7 | 20 |
| UCLA | 7 | 10 | 3 | 7 | 27 |
UCLA's unbeaten start has moved the Bruins firmly into the national conversation, and returning home gives them another favorable spot. Wisconsin has enough physicality to prevent this from becoming a rout, but UCLA should generate the better scoring opportunities.
ATS pick: UCLA -1.5
Louisville vs Syracuse AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Louisville | 7 | 10 | 10 | 7 | 34 |
| Syracuse | 3 | 7 | 0 | 7 | 17 |
Louisville has been inconsistent at times, but this is a favorable matchup against a Syracuse team that has struggled to defend explosive offenses. The Cardinals should be able to establish a lead early and force Syracuse into a more predictable passing script.
ATS pick: Louisville -14.5
Utah vs Colorado AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Utah | 7 | 14 | 7 | 7 | 35 |
| Colorado | 3 | 7 | 0 | 7 | 17 |
Utah remains unbeaten and brings one of the Big 12's most physical teams to Boulder. Colorado can create problems if this turns into an open game, but Utah should control possession and the line of scrimmage while keeping explosive plays to a minimum.
ATS pick: Utah -8.5
Nebraska vs Oregon AI prediction
| Team | 1Q | 2Q | 3Q | 4Q | Final |
|---|---|---|---|---|---|
| Nebraska | 3 | 7 | 3 | 7 | 20 |
| Oregon | 7 | 10 | 10 | 7 | 34 |
Oregon needs a response after a disappointing loss and gets the benefit of returning to Autzen Stadium. Nebraska has been competitive against quality opposition, but the Ducks still own the higher offensive ceiling and should be able to generate considerably more explosive plays.
ATS pick: Oregon -6.5
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