Week 12 of Monday Night Football features an NFC matchup between Carolina and San Francisco.
SBR's Gary Pearson breaks down the action in his Panthers vs 49ers prediction:
Over/Under pick: Under 49.5 (-108 via Caesars)
Game prediction: 49ers -7 (-120 via bet365)
"I love this matchup for the 49ers as the Panthers are in a prime letdown spot after the emotional high of orchestrating a comeback win over the Atlanta Falcons.
MNF marks the third away game in four for Carolina, which traveled to Green Bay and Atlanta with a home game against New Orleans sandwiched in between.
Dave Canales' team is also wildly inconsistent, allowing at least 26 points six times while conceding 17 or fewer in four of the other five.
Most of the poor defensive outings came against teams ranked in the top 10 of offensive DVOA. The Panthers allowed at least 27 points in three of those four games, including 42 against the New England Patriots (ranked 10th) and 40 versus the Buffalo Bills (ranked 4th).
The 49ers have the sixth-best offense in terms of DVOA, and they're the healthiest they've been all season. In his return, Brock Purdy led his team to 42 points last week against the Arizona Cardinals. Only once before had the 49ers scored more than 30.
While Carolina's offense has proven its ability to accumulate points, it has been as inconsistent as its defense, scoring 16 points or fewer six times. The 49ers have been waiting all season to show what they can do with a healthy offense, and I expect them to make the moment count on MNF."
Best prop bet: George Kittle Over 54.5 receiving yards (-114 via FanDuel)
"It took Kittle a while to get going after returning in Week 7 from a hamstring injury. He hit the Under on this 54.5-yard total in his first two games back, both away matchups. That's unsurprising considering he missed six weeks.
In the last two weeks, Kittle had 84 yards against the Los Angeles Rams at home and 67 on the road last week against the Cardinals. With game sharpness apparently back to peak level, Kittle must be salivating at the thought of facing a Carolina defense that allows the seventh-most yards to opposing tight ends."
Panthers vs. 49ers best odds

Panthers vs. 49ers betting trends
️Panthers vs. 49ers weather
The weather will be ideal for a prime-time football game, with the temperature at 59 degrees. There is no chance of precipitation, and winds are expected to gust to only 6 mph.
SBR's Gary Pearson breaks down the action in his Panthers vs 49ers prediction:
Over/Under pick: Under 49.5 (-108 via Caesars)
Game prediction: 49ers -7 (-120 via bet365)
"I love this matchup for the 49ers as the Panthers are in a prime letdown spot after the emotional high of orchestrating a comeback win over the Atlanta Falcons.
MNF marks the third away game in four for Carolina, which traveled to Green Bay and Atlanta with a home game against New Orleans sandwiched in between.
Dave Canales' team is also wildly inconsistent, allowing at least 26 points six times while conceding 17 or fewer in four of the other five.
Most of the poor defensive outings came against teams ranked in the top 10 of offensive DVOA. The Panthers allowed at least 27 points in three of those four games, including 42 against the New England Patriots (ranked 10th) and 40 versus the Buffalo Bills (ranked 4th).
The 49ers have the sixth-best offense in terms of DVOA, and they're the healthiest they've been all season. In his return, Brock Purdy led his team to 42 points last week against the Arizona Cardinals. Only once before had the 49ers scored more than 30.
While Carolina's offense has proven its ability to accumulate points, it has been as inconsistent as its defense, scoring 16 points or fewer six times. The 49ers have been waiting all season to show what they can do with a healthy offense, and I expect them to make the moment count on MNF."
Best prop bet: George Kittle Over 54.5 receiving yards (-114 via FanDuel)
"It took Kittle a while to get going after returning in Week 7 from a hamstring injury. He hit the Under on this 54.5-yard total in his first two games back, both away matchups. That's unsurprising considering he missed six weeks.
In the last two weeks, Kittle had 84 yards against the Los Angeles Rams at home and 67 on the road last week against the Cardinals. With game sharpness apparently back to peak level, Kittle must be salivating at the thought of facing a Carolina defense that allows the seventh-most yards to opposing tight ends."
Panthers vs. 49ers best odds
Panthers vs. 49ers betting trends
️Panthers vs. 49ers weather
The weather will be ideal for a prime-time football game, with the temperature at 59 degrees. There is no chance of precipitation, and winds are expected to gust to only 6 mph.
