| Fri., 9/7/12 | 8:00 PM | Utah | Utah State | ESPN2 |
| Sat., 9/8/12 | 12:00 PM | Auburn | Mississippi State | ESPN, ESPN3D |
| 12:00 PM | UCF | Ohio State | ESPN2 | |
| 12:00 PM | Penn State | Virginia | ABC | |
| 12:00 PM | Maryland | Temple | ESPNU | |
| 12:00 PM | New Hampshire | Minnesota | BTN | |
| 12:00 PM | Tulane | Tulsa | FSN | |
| 12:00 PM | To be announced | FX | ||
| 12:20 PM | East Carolina | South Carolina | SECN | |
| 12:20 PM | Ball State | Clemson | ACCN | |
| 3:00 PM | Sacramento State | Colorado | Pac-12 | |
| 3:00 PM | Eastern Washington | Washington State | Pac-12 | |
| 3:00 PM | Southern Utah | California | Pac-12 | |
| 3:30 PM | USC | Syracuse | ABC or ESPN2 | |
| Air Force | Michigan | |||
| 3:30 PM | Purdue | Notre Dame | NBC | |
| 3:30 PM | Florida | Texas A&M | ESPN | |
| 3:30 PM | Michigan State | Central Michigan | ESPNU | |
| 3:30 PM | South Florida | Nevada | CBSSN | |
| 3:30 PM | Iowa State | Iowa | BTN | |
| 3:30 PM | Western Kentucky | Alabama | SECN | |
| 3:30 PM | Delaware State | Delaware | NBCSN | |
| 3:30 PM | To be announced | FSN | ||
| 4:00 PM | Wisconsin | Oregon State | FX | |
| 6:30 PM | Fresno State | Oregon | Pac-12 | |
| 7:00 PM | Washington | LSU | ESPN | |
| 7:00 PM | UTEP | Mississippi | FSN | |
| 7:00 PM | Louisiana-Monroe | Arkansas | ESPNU | |
| 7:30 PM | Nebraska | UCLA | FOX | |
| 7:30 PM | Army | San Diego State | NBCSN | |
| 7:45 PM | Georgia | Missouri | ESPN2 | |
| 8:00 PM | Vanderbilt | Northwestern | BTN | |
| 8:00 PM | Louisiana Tech | Houston | CBSSN | |
| 10:30 PM | Illinois | Arizona State | ESPN | |
| 10:30 PM | Oklahoma State | Arizona | Pac-12 | |
| 10:30 PM | Duke | Stanford | Pac-12 | |