Atletico Madrid vs. Manchester United Prediction: Picks & Odds for Tuesday's Champions League
Last Updated: October 13, 2026 8:05 AM EDT • 3 minute read X Social Google News Link
Matchday 2 of the world’s best club competition is upon us, and I’m backing Diego Simeone’s side in my Atletico Madrid vs. Manchester United prediction.
Atletico Madrid are the -110 betting favorite to take care of business at Metropolitano Stadium in Madrid for Tuesday’s high-profile Champions League affair (3 p.m. ET, Paramount+).
I have my eyes on recent returnee Julian Alvarez to be the catalyst in helping Atleti secure a critical three points
Atletico Madrid vs. Manchester United predictions & best bets
See our experts' soccer picks.
| Best bets | Best odds | Wager (units) |
|---|---|---|
| Atletico Madrid ML | -110 via BetMGM | 1 unit to profit 0.91 units |
| Over 2.5 goals | -158 via FanDuel | 0.5 units to profit 0.32 units |
| Julian Alvarez goal or assist | -105 via FanDuel | 0.5 unit to profit 0.48 units |
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Atletico Madrid vs. Manchester United best bet
Check out all of our soccer betting analysis and expert predictions this season.
Atletico Madrid ML (-110 via BetMGM)
Atletico Madrid found their groove after an early-season blip, reeling off four straight wins after losing 2-1 to Liverpool at Anfield on Matchday 1.
The feather in their cap from that quartet came at home in the Madrid Derby, with Simeone’s side beating Real Madrid 2-1.
They won five of seven Champions League matches at home last season, and one defeat came in the quarterfinals against rampant Barcelona. Meanwhile, Manchester United are winless in four, with their previous victory coming against relative minnows Sabah in the Champions League.
The Red Devils haven’t won on their travels in the Premier League, losing once and drawing twice.
📡 SBR Edge: Travel woes
The Red Devils haven’t won on their travels in the Premier League, losing once and drawing twice. Atletico Madrid should defeat a slumping Manchester United that hasn’t won since beating Azerbaijan side Sabah FK in the Champions League over a month ago.
Score prediction: Atletico Madrid 2, Manchester United 1
More Atletico Madrid vs. Manchester United expert picks
Over 2.5 goals (-158 via FanDuel)
Manchester United have scored at least once in seven of their previous eight matches in all competitions, and I believe they’ll find a way to penetrate an Atletico Madrid side that have conceded at least once in six of their last eight games.
Atletico are also Over machines, with eight of nine games in all competitions seeing at least three goals. Simeone’s side is rolling offensively, scoring at least twice in eight of nine matches since the campaign kicked off.
Julian Alvarez goal or assist (-105 via FanDuel)
Alvarez was out of the lineup for two matches with a muscular injury, but returned to the lineup for Atletico’s 2-1 La Liga win over Real Madrid on Sept. 21.
He’s had two cameo appearances and featured in all three Argentina matches during the international break, scoring once.
He’ll be back to full fitness for Tuesday’s match, and Alvarez has been historically excellent in the Champions League, scoring six goals in the previous nine matches while adding three assists. That’s a goal contribution in every match over that sample size.
Atletico Madrid vs. Manchester United key stats
| Atletico Madrid | Manchester United | |
|---|---|---|
| Record (Champions League league phase) | 0-0-1 | 1-0-0 |
| Recent form (all comps) | WWWWL | DDLLW |
| Goals for (UCL) | 1 | 4 |
| xG (UCL) | 0.9 | 3.5 |
| Goals against (UCL) | 2 | 0 |
| xGA (UCL) | 1.6 | 0.8 |
Atletico Madrid vs. Manchester United odds
Atletico Madrid vs. Manchester United projected lineups
Here are the projected lineups for Atletico Madrid vs. Manchester United; subject to change:
| Atletico Madrid (3-4-2-1) | Manchester United (4-2-3-1) |
|---|---|
| Oblak (GK) | Lammens (GK) |
| Pubill (D) | Dalot (D) |
| Romero (D) | Maguire (D) |
| Hancko (D) | Martinez (D) |
| Grimaldo (M) | Shaw (D) |
| Simeone (M) | Mainoo (M) |
| Llorente (M) | Tielemans (M) |
| Cardoso (M) | Mbeumo (M) |
| Baena (M) | Fernandes (M) |
| Lee (M) | Rashford (M) |
| Alvarez (F) | Cunha (F) |
How to watch Atletico Madrid vs. Manchester United
- Date: Tuesday, Oct. 13
- Kickoff: 3 p.m. ET
- Location: Metropolitano Stadium (Madrid)
- TV/Streaming: Paramount+
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