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Seahawks vs. Broncos Prediction: Week 6 Odds, Picks & Best Bet

Our Seahawks vs. Broncos prediction for Week 6 includes our best bet, projected score, and the latest odds for Thursday's matchup.
Mike Spector
Mike Spector

Last Updated: October 15, 2026 10:00 AM EDT • 2 minute read

Denver Broncos quarterback Bo Nix (10) throws a pass against the Los Angeles Chargers as we make our best Seahawks vs. Broncos prediction.
Pictured: Denver Broncos quarterback Bo Nix (10) throws a pass against the Los Angeles Chargers as we make our best Seahawks vs. Broncos prediction. Photo by William Liang-Imagn Images.
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It’s a high-profile Thursday Night Football matchup between last year’s two No. 1 seeds, with the Denver Broncos hosting the Seattle Seahawks. My Seahawks vs. Broncos prediction backs the home underdogs in this possible Super Bowl preview, citing Seattle's tough situational spot on a short week. Read on to learn why I expect the historic underdog run in primetime games to continue.

Kickoff from Empower Field at Mile High in Denver is set for 8:15 p.m. (Prime Video). Seattle is a 2.5-point betting favorite.

Seahawks vs. Broncos picks & predictions

See all of our experts' NFL picks for Week 6 based on the latest NFL odds.

Pick Bet size
Broncos +2.5 (-102 via FanDuel) 1 unit to win 0.98 units
Under 40.5 (-105 via FanDuel) 1 unit to win 0.95 units

Total wagered: 2 units | Max profit: +1.93 units

Seahawks vs. Broncos prediction & best bet

Broncos +2.5 (-102 via FanDuel)

Seattle is 12-1 against AFC teams under head coach Mike Macdonald and hasn't lost back-to-back games since 2024. But this is a tough spot for the Seahawks after a deflating divisional home loss to the 49ers, while the Broncos won convincingly despite only managing 224 yards last week.

The Seahawks’ turnover issues are becoming crippling. Sam Darnold has thrown five interceptions since returning from injury in Week 3, and the team is tied for the most turnovers in the league over that span. Meanwhile, Denver’s defense forced three turnovers in the fourth quarter alone last week and could turn the tide in this game with more turnover fortune.

In a game that projects to be close, I will back a Broncos team that has won 13 straight one-score games.

📡 SBR Edge: Prime-time underdogs

Underdogs have won seven straight games outright in prime-time at night, the longest such streak since the merger.

Don't count out Bo Nix

Bo Nix has averaged 5.8 yards per attempt this season, which ranks 28th out of 31 qualified quarterbacks. The lack of a downfield passing threat is a big reason why the Broncos are in the bottom 10 of offensive success rate, EPA per play, yards per play, and points per drive.

However, I expect positive regression from Nix in the second game since head coach Sean Payton returned to play-calling duties. Nix is 10-0 in his last 10 games against NFC opponents since Week 3 of 2024, with 26 passing and rushing touchdowns and just three turnovers. Nix is also never out of a game, having already led three fourth-quarter comebacks this season.

Score prediction: Broncos 21, Seahawks 17

Seahawks vs. Broncos odds

Seahawks vs. Broncos opening odds

  • Moneyline: Seahawks -135 | Broncos +110
  • Spread: Seahawks -2 (-110) | Broncos +2 (-108)
  • Over/Under: Over 42 (-110) | Under 42 (-108)

How to watch Seahawks vs. Broncos: Week 6

  • Date: Thursday, Oct. 15
  • Kickoff: 8:15 p.m. ET
  • Location: Empower Field at Mile High (Denver)
  • Streaming: Prime Video

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Written by:
Mike Spector
Mike started in the sports writing industry in July 2019, and gained a lot of followers in his first year after finishing with the No. 2 overall record in an annual NFL betting competition, which made picks against the spread, and from an Over/Under and moneyline perspective. Mike is an avid fan of the NFL, MLB, tennis, and all college sports. In his opinion, March Madness is the best sporting event there is, and he's especially euphoric starting with conference tournament time in college basketball. Mike's a big advocate of "fading the public" and making plays that are contrarian, constantly citing that "there are reasons why they have those big shiny buildings in Las Vegas." When making wagers, Mike leans on his NFL experience and always scours the best odds at all of the major sports betting sites, where he mostly sifts through DraftKings, FanDuel, BetMGM, and bet365. He's tried several others and is of the firm belief that bettors should not just stick to one sportsbook, as there is always likely better value to be had with the same wager. In addition, while Mike received his undergraduate degree from Villanova University, he has no issue betting against the Wildcats when it comes to college basketball wagering, and suggests other bettors should always put their “head” before their “hearts.”