Patriots vs. Seahawks Prediction & Opening Odds: NFL Opening Game Preview, Expert Pick
The Patriots vs. Seahawks prediction and opening odds take center stage as the 2026 NFL season kicks off with a highly anticipated Super Bowl LX rematch. New England travels to Seattle on Wednesday, September 9, with kickoff scheduled for 8:20 p.m. ET from Lumen Field.
The game will be televised nationally on NBC and Peacock, giving football fans an immediate marquee matchup to open the season. Seattle enters as the defending Super Bowl champion after defeating New England seven months ago, setting the stage for an intriguing rematch. The Seahawks opened as 3.5-point home favorites, with a 44.5-point total.
🏈 Patriots vs. Seahawks early prediction: NFL opening night
See the latest NFL odds and our experts' NFL picks for every game this season.
Patriots +3.5 (-110)
The Patriots are the side to back at +3.5 because this matchup should be much closer than the Super Bowl result suggests. New England went 14-3 during the 2025 regular season and returns with Drake Maye entering his second season, giving the offense a quarterback capable of making plays against Seattle’s defense.
The Seahawks also lost Super Bowl MVP Kenneth Walker III in free agency, creating a significant change in their offensive identity heading into the rematch. With the spread sitting above a field goal, the Patriots have valuable cushion in what should be a competitive game. Mike Vrabel’s team has enough offensive firepower and defensive talent to keep this within one score and cover +3.5.
📊 Patriots vs. Seahawks odds: NFL opening night
Patriots vs. Seahawks odds update live in real time. Our NFL analysis and expert predictions cover every game this season.
Patriots vs. Seahawks opening odds
- Moneyline: Patriots +150 | Seahawks -180
- Spread: Patriots +4 (-110) | Seahawks -4 (-110)
- Over/Under: Over 44.5 (-105) | Under 44.5 (-115)
I expect these numbers to hold relatively steady leading up to kickoff. The prices shouldn’t vary too much, especially with the Patriots currently sitting at +3.5. Since New England opened at +4, getting the Patriots at +3.5 still provides solid value, particularly if the line moves back toward the opener.
📺 How to watch Patriots vs. Seahawks: NFL opening night
- Date: [DAY, MONTH DATE]
- Kickoff: [X:XX x.m. ET]
- Location: [STADIUM (City, State)]
- TV: [TV network]
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