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Cardinals vs. Giants Prediction: Week 4 Odds, Picks & Best Bet

Our Cardinals vs. Giants prediction for Week 4 includes our best bet, projected score, and the latest odds for Sunday's matchup.

Matt MacKay

Last Updated: October 3, 2026 3:00 PM EDT • 2 minute read

Pictured: Jacoby Brissett throws a pass as we break down our Cardinals vs. Giants Prediction. Photo by Darren Yamashita-Imagn Images.

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An NFC interdivisional matchup heads to the Meadowlands in Week 4 with my Cardinals vs. Giants prediction. Jacoby Brissett leads Arizona's high-flying offense against the 2-1 Giants, who just beat the Titans without scoring a touchdown.

The Cardinals are -2.5-point road favorites at MetLife Stadium in East Rutherford, N.J., with the opening kickoff set for Sunday at 1:00 p.m. ET (CBS).

🏈 Cardinals vs. Giants picks & predictions

See all of our experts' NFL picks for Week 4 based on the latest NFL odds.

Pick	Bet size
Cardinals -2.5 (-110 via FanDuel)	1.10 units
Under 44.5 (-112 via DraftKings)	2.24 units

Total wagered: 3.34 units | Max profit: 3.0 units

💰 Cardinals vs. Giants prediction & best bet

Under 44.5 (-112 via DraftKings)

The Cardinals' offense will look to stay hot in Week 4, coming off a season-high 30 points on the road against the 49ers. Brissett has cleared 270 passing yards twice this season, however, rain showers and 10 mph winds are in the forecast for Sunday's road trip to MetLife.

Cam Skattebo and Najee Harris played an ugly game against the Titans, logging 29 carries for 112 rushing yards. The Giants' offense settled for four field goals, while the defense forced a key red-zone takeaway at the end of the game.

Jameis Winston's play has been bad, to say the least. He hasn't surpassed 118 passing yards in either start following Jaxson Dart's injury. It feels like we're only a couple of bad starts away from seeing J.J. McCarthy's Giants debut.

Arizona's defense has a chance for a bounce-back spot against a struggling Giants offense this week. Plus, John Harbaugh's defense has held the Cowboys and Titans to under 100 rushing yards and 200 passing yards.

Let's bet Under 44.5 on DraftKings at -112 odds as the best bet in this matchup.

📡 SBR Edge: G-Men Unders

Following a win, the Giants have gone Under the point total line in 12 of their previous 16 games played.

Winston's struggles continue

The Giants' offense relied heavily on the run game in Week 3. It led to a win. Four field goals won't get it done against a Cardinals passing attack that just logged 272 passing yards against the 49ers.

Arizona's defense plays its best game of the season against Winston's inaccurate passing. The Cardinals improve to .500 with a 27-16 win over the Giants.

Score prediction: Cardinals 27, Giants 16

📊 Live Cardinals vs. Giants odds

See the latest NFL odds for every Week 4 matchup.

Cardinals vs. Giants opening odds

Moneyline: Cardinals +125 | Giants -150
Spread: Cardinals +2.5 (-112) | Giants -2.5 (-108)
Over/Under: Over 43.5 (-115) | Under 43.5 (-105)

📺 How to watch Cardinals vs. Giants: Week 4

Date: Sunday, Oct. 4
Kickoff: 1:00 p.m. ET
Location: MetLife Stadium (East Rutherford, N.J.)
TV: CBS

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Written by:
Matt MacKay

Matt MacKay has handicapped golf, the NFL, NCAAF, and NHL since joining the sports betting industry as a writer in 2020. He’s worked for several prominent sites, recently expanding his coverage to include sports betting news and the regulatory industry. Bringing a background in communications and writing, earning a Masters Degree in Organizational Communication from Ohio University, Matt has co-hosted a fantasy football and sports betting podcast, while continuously refining his handicapping methods. This includes identifying recent trends, head-to-head statistics, and comparing individual and team strengths and weaknesses to accurately predict the outcome in certain betting markets before a game or event. He’s a daily bettor and tends to wager on FanDuel, with DraftKings and Hard Rock Bet as preferred sports betting app alternatives. An avid researcher, writer, editor, and podcaster, Matt is eager to dig into matchups to offer readers and subscribers value on his picks. He’s a big proponent of building bankroll by avoiding poor betting habits and tendencies, like chasing losses, placing too many wagers, and managing bankroll. His worst beats to date both came on two separate NFL parlays, losing due to Tyreek Hill and A.J. Brown dropping passes. NRFIs have quickly become one of Matt’s favorite betting markets, recently diving into MLB game props.