Best March Madness Parlay Picks for Round 1: Our Best Bet at +905 Odds

Now that you’ve filled out your NCAA Tournament bracket, check out our March Madness parlay picks, which combine our best moneyline picks from the first round into one juicy parlay.

As part of our March Madness predictions, we’re riding a pair of small moneyline favorites and one heavy underdog for a parlay that pays out with +905 odds at DraftKings.

🏀 Best March Madness parlay for NCAA Tournament first round

Here are my three best March Madness moneyline picks for the first round of the NCAA Tournament along with the best single-leg and parlay odds from our best sports betting sites.

🚀 Parlay pick #1: No. 11 North Carolina over No. 6 Ole Miss

🗓️ Game info: Friday, 4:05 p.m. ET (TNT)
📊 Best odds: -120 via FanDuel

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After everyone’s favorite 'undeserving' blue blood snuck into the tournament field, North Carolina put its best foot forward in Tuesday’s First Four game against San Diego State, demolishing the Aztecs to reach the Round of 64.

Although the emphatic nature of the Tar Heels’ win has steamed them up to 1.5-point betting favorites over the No. 6 seed Ole Miss Rebels, we still don’t mind the value of their -120 moneyline odds.

Since the First Four began in 2011, 12 of 26 (46.1%) at-large participants advanced beyond the Round of 64. UNC lands just a handful of spots behind Ole Miss in the KenPom rankings and has momentum after a tremendous showing in Dayton, Ohio.

See Phil Wood's Ole Miss vs. North Carolina prediction.

🚀 Parlay pick #2: No. 8 UConn over No. 9 Oklahoma

🗓️ Game info: Friday, 9:25 p.m. ET (TNT)
📊 Best odds: -220 via BetMGM

The two-time defending national champions played around with their food this season, but the UConn Huskies still have one of the most efficient offenses in college basketball (14th adjusted offensive efficiency per KenPom).

Oklahoma ranks 322nd in the nation in two-point defense, an area that UConn can exploit against the Sooners. The Huskies are 16th in the country in two-point shooting percentage.

OU struggled to take down quality competition as the Sooners finished just 6-12 in their conference slate and went 4-10 against teams who ended up with a better NCAA Tournament seed than they did.

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🚀 Parlay pick #3: No. 13 High Point over No. 4 Purdue

🗓️ Game info: Thursday, 12:40 p.m. ET (truTV)
📊 Best odds: +300 via FanDuel

We’re including one notable upset pick in our parlay to juice up the odds, and it’s actually the game that tips off first among the three picks.

On Thursday afternoon, we expect this High Point team that ranks 12th in the country in effective field goal percentage and 46th in the land in 3-point percentage to give Purdue all it can handle.

As an 8.5-point betting underdog, High Point is +300 on the moneyline at FanDuel to pull off what would go down as one of the biggest stunners of the tournament. But Purdue is no stranger to upset victimhood in March, and this year’s Boilermaker group has flaws defensively, ranking 348th in two-point defense.

See my Purdue vs. High Point prediction.

💰 Best March Madness first round moneyline parlay

We're combining our three best March Madness picks into a lucrative parlay with +905 odds via DraftKings, which would turn a $10 bet into a $90.50 profit if all three teams win in the first round of the NCAA Tournament.

🔥 Parlay: UNC ML + UConn ML + High Point ML (+905 via DraftKings)

💰 Wager $10 → Win $90.50
💰 Wager $50 → Win $452.50

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👉 Want to build a bigger parlay or add more bets for your parlay? Use our parlay calculator to find the best odds. Check out our latest college basketball picks and the rest of our March Madness first-round picks.    

🔮 March Madness predictions for every game today

• Louisville vs. Creighton prediction
• Purdue vs. High Point prediction
• Wisconsin vs. Montana prediction
• Houston vs. SIU Edwardsville prediction
• Auburn vs. Alabama State prediction
• Clemson vs. McNeese prediction
• BYU vs. VCU prediction
• Gonzaga vs. Georgia prediction
• Tennessee vs. Wofford prediction
• Kansas vs. Arkansas prediction
• Texas A&M vs. Yale prediction
• Missouri vs. Drake prediction
• UCLA vs. Utah State prediction
• St. John's vs. Omaha prediction
• Michigan vs. UC San Diego prediction
• Texas Tech vs. UNC Wilmington prediction

👑 Best March Madness betting sites

Ready to place your March Madness bets? Check out the best March Madness betting promos from our best March Madness betting sites, as determined by our expert team at Sportsbook Review.

• Caesars Promo Code: SBRBONUSDYW | Read our Caesars Review
• BetMGM Bonus Code: SBRBONUS | Read our BetMGM Review
• bet365 Bonus Code: SBRBONUS | Read our bet365 Review
• FanDuel Promo Code | Read our FanDuel Review
• DraftKings Promo Code | Read our DraftKings Review

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