Ole Miss vs. Vanderbilt Prediction: Week 6 Odds, Picks & Best Bet
Trinidad Chambliss has had to sit with a bad taste in his mouth for two weeks as the Rebels prepare for their second straight conference road trip in my Ole Miss vs. Vanderbilt prediction. No. 9 Ole Miss got dominated by No. 16 Florida during their last contest, losing 52-28, while Vanderbilt is 0-2 in conference play against Auburn and No. 2 Georgia.
Ole Miss is a -9.5 point road favorite at FirstBank Stadium in Nashville, Tenn., with opening kickoff set for Saturday at 3:30 p.m. ET (ESPN).
Ole Miss vs. Vanderbilt picks & predictions
See all of our experts' college football picks for Week 6 based on the latest college football odds.
| Pick | Bet size |
|---|---|
| Vanderbilt +9.5 (-108 via FanDuel) | 1.08 units to win 1.00 units |
| Over 55.5 (-105 via DraftKings) | 2.10 units to win 2.00 units |
Total wagered: 3.18 units | Max profit: +3.00 units
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Ole Miss vs. Vanderbilt prediction & best bet
Check out all of our college football predictions for more analysis across this week's slate.
Over 55.5 (-105 via DraftKings)
Chambliss is among the highest-paid quarterbacks in the current NIL landscape and it's justified based on his play. The Ole Miss signal-caller has thrown for over a 70 percent completion rate and 1,200 yards in just 4 starts.
Now, the Rebels take on a Vanderbilt defense that has allowed 7 passing touchdowns in its previous 3 combined outings, including 280+ passing yards to NC State and Georgia. The Commodores also struggle to stop the run, giving up 4.0 YPC or more during this recent 3-game stretch.
Ole Miss certainly doesn't have a stout defense, which is why we could see Vanderbilt cover +9.5, as they are undefeated at home. The Rebels have allowed over 30 points per game, ranked 117th amongst 136 FBS teams in 2026.
Since opening, the total points line has moved from 57.5 to 55.5. There's value in taking Over 55.5 right now, so let's go to DraftKings for the best price and bet Over 55.5 at -105 odds.
📡 SBR Edge: Run, Rebel, Run
Ole Miss has allowed 4.0 YPC or more in every game played this season.
Ole Miss and Chambliss Avoid a Scare During High-Scoring Shootout in Nashville
It's going to be another back-and-forth game involving Ole Miss. Vanderbilt's offense will finally be able to stay ahead of schedule after facing two tough defenses like Auburn and Georgia. The Commodores have recorded 28+ points at home in every game played this year.
Chambliss is the best player on the field in this matchup. However, the porous Rebels defense will allow Vanderbilt to hang around, leaning on their rushing attack and avoiding miscues on offense to keep pace with Ole Miss.
Score prediction: Ole Miss 41, Vanderbilt 34
Live Ole Miss vs. Vanderbilt odds
Ole Miss vs. Vanderbilt opening odds
- Moneyline: Ole Miss -430 | Vanderbilt +330
- Spread: Ole Miss -10.5 (-105) | Vanderbilt +10.5 (-115)
- Over/Under: Over 57.5 (+100) | Under 57.5 (-120)
How to watch Ole Miss vs. Vanderbilt: Week 6
- Date: Saturday, Oct. 10
- Kickoff: 3:30 p.m. ET
- Location: FirstBank Stadium (Nashville, Tenn.)
- TV: ESPN
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