NFL Odds & Week 5 Schedule | Betting Lines, Spreads and Totals for Every Game
📊 NFL odds Week 5, 2026
The NFL odds for Week 5 are via bet365.
| Game | Spread | Moneyline | Over/Under |
|---|---|---|---|
| Buccaneers vs. Cowboys (TNF) | Cowboys -9.5 | TB +450 / DAL -600 | 47.5 |
| Eagles vs. Jaguars (from London) | Jaguars -4.5 | PHI +185 / JAX -225 | 43.5 |
| Bears vs. Packers | Bears -2.5 | CHI -140 / GB +120 | 44.5 |
| Bengals vs. Dolphins | Bengals -7.5 | CIN -390 / MIA +310 | 41.5 |
| Browns vs. Jets | Jets -1.5 | CLE +110 / NYJ -130 | 40.5 |
| Texans vs. Titans | Texans -6.5 | HOU -300 / TEN +240 | 39.5 |
| Colts vs. Steelers | Steelers -2.5 | IND +115 / PIT -135 | 44.5 |
| Raiders vs. Patriots | Patriots -3.5 | LV +155 / NE -185 | 44.5 |
| Vikings vs. Saints | Vikings -1.5 | MIN -125 / NO +105 | 42.5 |
| Giants vs. Commanders | Commanders -3.5 | NYG +150 / WSH -180 | 43.5 |
| Broncos vs. Chargers | Broncos -3.5 | DEN -180 / LAC +150 | 42.5 |
| Lions vs. Cardinals | Lions -5.5 | DET -245 / ARI +200 | 54.5 |
| 49ers vs. Seahawks | Seahawks -2.5 | SF +125 / SEA -150 | 47.5 |
| Ravens vs. Falcons (SNF) | Ravens -3.5 | BAL -200 / ATL +165 | 46.5 |
| Bills vs. Rams (MNF) | Rams -2.5 | BUF +125 / LAR -150 | 53.5 |
Our NFL picks will be locked and loaded for Week 5 as bye weeks get underway.
- The Buccaneers look to avoid a fifth-straight loss when they visit the Cowboys (-9.5) on Thursday Night Football; kickoff from AT&T Stadium at 8:15 p.m. ET (Prime Video)
- A second straight London game opens Sunday as the Jaguars (-4.5) and Eagles clash at Tottenham Hotspur Stadium; kickoff at 9:30 a.m. ET (NFL Network)
- A battle of the birds on Sunday Night Football with the Ravens (-3.5) lined as road favorites at the Falcons; kickoff from Mercedes-Benz Stadium at 8:20 p.m. ET (NBC)
- Two top Super Bowl contenders close the week when the Bills visit the Rams (-2.5) on Monday Night Football; kickoff from SoFti Stadium is at 8:15 p.m. ET (ESPN/ABC)
- The AFC West-leading Kansas City Chiefs (4-0) and NFC South-leading Carolina Panthers (2-2) are the first teams on bye for the season
🏈 Buccaneers vs. Cowboys: Thursday Night Football
- Kickoff: 8:15 p.m. ET from AT&T Stadium (Arlington, Texas)
- How to watch: Prime Video
🏈 Eagles vs. Jaguars in London
- Kickoff: 9:30 a.m. ET from Tottenham Hotspur Stadium (London)
- How to watch: NFL Network
🏈 Ravens vs. Falcons: Sunday Night Football
- Kickoff: 8:20 p.m. ET from Mercedes-Benz Stadium (Atlanta)
- How to watch: NBC
🏈 Bills vs. Rams: Monday Night Football
- Kickoff: 8:15 p.m. ET from SoFi Stadium (Inglewood, Calif.)
- How to watch: ESPN/ABC
📈 NFL Week 5 odds and lines
There's an advantage to betting early NFL odds when attempting to beat the closing line with your NFL predictions. The closer you wait until kickoff to make your picks, the harder it becomes to identify edges and secure the best price on most sides or totals.
📺 Who's playing on prime time in Week 5?
We have a fourth prime-time game in Week 5 to join Thursday Night Football, Sunday Night Football, and Monday Night Football. The NFL International Series continues with a standalone game on Sunday morning in Londo with the Jaguars vs. the Eagles.
The week opens with a showdown between the Buccaneers and the Cowboys on Thursday Night Football. Sunday wraps up with the Baltimore Ravens vs. Atlanta Falcons on Sunday Night Football. The 15-game slate finishes with the Los Angeles Rams vs. the Buffalo Bills on Monday Night Football in a potential Super Bowl battle.
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