NFL Moneyline Picks for Week 5: Best Bets to Win Every Game
Week 5 could be the week of the underdog, as my NFL moneyline picks back seven 'dogs to win straight up.
Alongside my moneyline predictions for every game on this week's slate are breakdowns of my three favorite targets, including Sunday Night Football and Monday Night Football. Let's dive in.
NFL moneyline picks: Week 5
See all of our experts' NFL picks for Week 5 based on the latest NFL odds.
| Matchup | Pick | Confidence |
|---|---|---|
| Buccaneers vs. Cowboys | Cowboys -470 | ⭐⭐⭐⭐ |
| Eagles vs. Jaguars | Jaguars -290 | ⭐⭐⭐⭐ |
| Bears vs. Packers | Packers +130 | ⭐⭐⭐ |
| Texans vs. Titans | Texans -345 | ⭐⭐⭐ |
| Bengals vs. Dolphins | Bengals -345 | ⭐⭐⭐⭐⭐ |
| Raiders vs. Patriots | Patriots -192 | ⭐⭐⭐⭐ |
| Vikings vs. Saints | Saints +105 | ⭐⭐ |
| Browns vs. Jets | Jets -130 | ⭐⭐ |
| Colts vs. Steelers | Colts +114 | ⭐⭐⭐ |
| Giants vs. Commanders | Commanders -166 | ⭐⭐⭐ |
| Broncos vs. Chargers | Chargers +154 | ⭐⭐ |
| Lions vs. Cardinals | Lions -225 | ⭐⭐⭐⭐⭐ |
| 49ers vs. Seahawks | 49ers +124 | ⭐⭐ |
| Ravens vs. Falcons | Falcons +114 | ⭐⭐⭐⭐ |
| Bills vs. Rams | Bills +130 | ⭐⭐⭐ |
💡 More Week 5 predictions
Want more NFL betting advice? Check out all of our NFL analysis and expert predictions for every game in Week 5.
My best NFL Week 5 moneyline bets
Bills (+120) vs. Rams ⭐⭐⭐
It's a treat getting a Josh Allen-led team at plus-money, even on the road against a fellow Super Bowl contender.
If anything, the fast turf of the Rams' SoFi Stadium field favors Buffalo's explosive offense. The Bills have the league's second-highest explosive play rate this season.
Allen has been a bit sloppy with the football lately, but turnovers are the only thing keeping the Bills from scoring 30 every game. L.A.'s defense is banged up and only has three takeaways; I like Allen's chances of outdueling Matthew Stafford and winning on the road.
Falcons (+114) vs. Ravens ⭐⭐⭐⭐
Who would have thought the Falcons could win their straight prime-time game after blowing out the Packers and Saints on the road in back-to-back weeks?
Now they return to Atlanta for a Sunday night matchup against a Ravens team that could be without Lamar Jackson. The former NFL MVP has a sprained ankle and reportedly could miss multiple games.
I don't see Baltimore keeping pace with a Falcons offense that is firing on all cylinders since Michael Penix Jr. returned. Atlanta ranks second in the NFL in rushing yards and yards per attempt.
Packers (+130) vs. Bears ⭐⭐⭐
This is the first time since 2024 that the Packers are home underdogs, because they have been nearly unbeatable in Wisconsin. Green Bay has a .741 winning percentage at home under Matt LaFleur.
Meanwhile, the Bears are 1-9 in their last 10 trips to Lambeau Field. And in that lone Chicago win, Jordan Love exited the game before halftime.
This is a tough place to play for any opponent, but especially for the Packers' arch rival. Green Bay's home crowd will be impactful and help the Packers make a statement at home.
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