The Houston Astros are the biggest favorites of the season today against the Baltimore Orioles. The Astros closed as -450 favorites at Caesars Sportsbook. Other sportsbooks went even higher, listing Houston as high as -550 at Station Casinos sportsbooks in Nevada. The Los Angeles Dodgers were -485 favorites over the Atlanta Braves in 2016, the largest price on a favorite in an MLB game in at least the last 15 seasons.