Spurs should win this one comfortably if they want to keep up. They have a tough match at Anfield next round and Wigan is as easy as they come. Wigan did not win in their last 7 matches and failed to score in recent games against top teams (City 0-1, Man U 5-0, Liver 0-0, but Chelsea 1-1).
I think Tottenham will play this game with minimum risk. The spread suggest a high potential of a big win and the total is affected too much by this. Taking the under here since Spurs will look for a controlling win rather than a crazy match.
Their game against Manchester City was the first match in last 8 to go over 2.5 goals. 73% of Wigan's matches away had over 2.5 goals scored in total!