Top 4 games that stand out to me (in no order) are:
Cincinnati +4.5 / New England -4.5
Brady is 21-3 (16-0 past two seasons) at home SU in his past 3 years as a starter. New England failed to make the playoffs last year and in my opinion, that's their sole motivation to jump out with a statement game this week. There's many questions shadowing the Bengals and unfortunately those questions will remain answerless till this season progresses. Ill keep this short and say NE wins 31-17
Oakland +6 / Tennessee -6
Its been 7 years since Oakland has won its opening game. To keep it simple, they're not winning Sunday. This team has the make up of a promiscuous teenage girl undergoing an identity crisis. Tenn handles them easy, I see a 27-10 boxscore.
Seattle +3 / 49ers -3
I like the 49ers here but this game should be approached very cautiously. The 49ers are terrible on the road. They went 2-6 last year and split with Seattle who was 4-4 at home (beating sanfran once). Seattle won its last two home openers (2009 Rams, 2007 Bucs). To wrap it up, I feel Mike Singletary is progressing as a coaching and his team is evolving into a wild card / playoff team. I see him welcoming Pete Caroll to the NFL with a 24-13 win for San Fran.
Green Bay -3 / Eagles +3
Green Bay routes Philly. This is a game I expect Philly to remain close in the first half but when GB's defense settles down and times Kolb's passing, its going to turn into a long day. Rogers wont be stopped and GB will put the clamps on when Philly has to pass to attempt a comeback. Rodgers: 3TD's Kolb: 2TD's 2Int's. My score reads 37-24 GB (Philly scores late to make it look respectable)