If Andrew Luck doesn't play, that's obviously the most important piece of the Indy puzzle and he single handedly keeps that team from being dreadful. Apart from that you have one of their best linemen in Ryan Kelly out, further complicating what was already a weakness. Now let's just throw their best defensive back Vontae Davis into the mix for good measure.
I mean if the Rams at home on opening weekend can't find a way to upend this handicapped shell of a team, then they might as way mail it in the rest of the season because it's not like the road gets much easier from there.
I guess all we need now is a pointspread?