I'm just popping this one in ahead of the game:
San Diego @ Tennessee
Two teams who stack up pretty similiarly in strength according to the numbers I use. All but impossible not to support the team with home advantage who have their possible playoff lives on the line, versus visitors with virtually zip to play for who'll be wishing they were at home eating Christmas dinner with their loved ones (in Rivers' case, that's himself).
Titans -3 for 8 units