Leaning Indiana -1.5 in this one, and here's why.
Iowa's defense has struggled against teams that can pass the ball. Radcliff of Central Michigan went 26/35 283 yards 2 TD 0 INT, and Iowa lost that game. Matt McGloin of PSU went 26/38 289 yards 2 TD 0 INT in a 38-14 rout in Iowa City. Indiana's pass offense ranks #30 in the nation. Regardless of who is QB, Coffman or the surprising freshman Sudfield, they should find holes in that Iowa secondary.
At first glance, it appears that Indiana struggles at defending the run, as they rank #114 in rushing yards per game allowed. However, majority of those yards were given up to teams like Northwestern, Ohio State, and Navy. All of these teams run the ball much differently than Iowa. Northwestern and Ohio State have mobile QB's that run the zone-read option. Navy runs the ball 75% of the time with their triple option attack. Iowa has a downhill, I-formation running game that is similar to Michigan State. Indiana held MSU and their stud running back, Bell, to only 2.9 yards per carry. Also, Iowa's lone bright spot on offense, RB Weisman, is doubtful to play in this game. If Indiana can limit the Hawkeyes on the ground, I'm not sure Vandenberg can keep Iowa in it with his arm.
All of a sudden, Indiana has a lot to play for in the Big Ten Leaders division. After Wisconsin's loss last week, Indiana is now in the mix to challenge the Badgers for a spot in the Big Ten title game. They should be fired up and ready to go in this game. Meanwhile, Iowa is sliding out of contention in their division. They are banged-up and playing back to back road games, and they struggle away from home as is.