Serious question.
Obviously, you're playing the guys you drafted early, as they are the "big-names" that I speak about, e.g. Fitzgerald, or do you play each week differently depending on your roster and the matchups presented? Probably most just play the "big-names" each week without thinking twice, because in a way they're forced to. This is just one of the many headaches associated with fantasy football.
The one person this applies to me with is damn Fitzgerald. Do I play Fitzgerald tomorrow or Aldrick Robinson (because the Bengals allowed Weeden to throw for 322 yards with 2TDs after coming off a 4picks no TDs performance )