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The Jacksonville Jaguars and quarterback Trevor Lawrence are a home favorite over the Cincinnati Bengals in the NFL Week 13 odds & betting lines.
Trevor Lawrence of the Jacksonville Jaguars runs onto the field before the game against the Houston Texans. Photo by Mike Carlson via Getty Images/AFP.

Here's our analysis of the NFL Week 13 odds and betting lines from our best NFL betting sites. The action starts with an NFC showdown between the Seattle Seahawks and Dallas Cowboys and concludes with a Monday Night Football matchup featuring the Cincinnati Bengals and Jacksonville Jaguars.

The marquee matchup of Week 13 pits the San Francisco 49ers against the Philadelphia Eagles at Lincoln Financial Field, and the NFC bout will significantly impact the Super Bowl odds and NFL MVP odds.

There would have been similar AFC implications in the Monday Night Football matchup between the Cincinnati Bengals and Jacksonville Jaguars. But Bengals quarterback Joe Burrow (wrist) is out for the season, and the Jags are among the largest favorites on the docket. 

Instead, it’s another AFC meeting between a pair of 6-5 teams with sneaky postseason drama attached. The Denver Broncos visit the Houston Texans, with Houston will be looking to bounce back with a Week 13 win, while Denver is seeking its sixth straight victory.

Additionally, two other NFC games feature a pair of likely playoff teams in tape-measuring matchups. The week opens with the Seattle Seahawks visiting the Dallas Cowboys for a Thursday Night Football tilt, and the New Orleans Saints host the Detroit Lions in another important contest after both teams lost in Week 12.

Here’s a closer look at all of the NFL Week 13 odds from our best sports betting sites.

NFL Week 13 odds and lines

There's an advantage to betting the early NFL odds while trying to beat the closing line. The closer you wait until kickoff to make your NFL picks, the more difficult it becomes to identify edges and secure the best number on most sides or totals.

That's why it's important to start monitoring the NFL opening odds each week as soon as possible. A proactive approach is the first step to long-term success.

Best NFL Week 13 spreads

(Odds via Caesars)

GameSpread (Nov. 28)Opening spread (Nov. 22)
Seahawks vs. CowboysCowboys -9Cowboys -7
Colts vs. TitansTitans +2Titans +1
Chargers vs. PatriotsPatriots +6Patriots +4.5
Lions vs. SaintsSaints +4Saints +3
Falcons vs. JetsJets +2.5Jets +1.5
Cardinals vs. SteelersSteelers -5.5Steelers -3
Dolphins vs. CommandersCommanders +9.5Commanders +7
Broncos vs. TexansTexans -3.5Texans -3
Panthers vs. BuccaneersBuccaneers -5.5Buccaneers -5.5
Browns vs. RamsRams -4Rams -1
49ers vs. EaglesEagles +2.5Eagles -1.5
Chiefs vs. PackersPackers +6.5Packers +7
Bengals vs. JaguarsJaguars -8.5Jaguars -7

There are six home underdogs still remaining from the opening Week 13 odds, and there also aren’t many lopsided spreads. Just the Cowboys, Jaguars, and Miami Dolphins are favorites of greater than a touchdown.

Additionally, there are now only three games with the margin at or below a field goal, including the noted NFC 49ers-Eagles showdown. There were seven in the opening odds.

Best NFL Week 13 moneylines

(Odds via DraftKings)

GameMoneyline (Nov. 28)Opening moneyline (Nov. 22)
Seahawks vs. CowboysCowboys -455Cowboys -285
Colts vs. TitansTitans +114Titans -110
Chargers vs. PatriotsPatriots +210Patriots +160
Lions vs. SaintsSaints +164Saints +130
Falcons vs. JetsJets +124Jets +105
Cardinals vs. SteelersSteelers -238Steelers -180
Dolphins vs. CommandersCommanders +350Commanders +240
Broncos vs. TexansTexans -192Texans -155
Panthers vs. BuccaneersBuccaneers -238Buccaneers -258
Browns vs. RamsRams -175Rams -120
49ers vs. EaglesEagles +130Eagles -125
Chiefs vs. PackersPackers +230Packers +240
Bengals vs. JaguarsJaguars -380Jaguars -278

The Cowboys, Dolphins, Jaguars, and Chiefs are the largest favorites in Week 13. Additionally, the Tennessee Titans and Philadelphia moved from a home favorite to a home underdog, while the line moved further in the direction of the Pittsburgh Steelers and Los Angeles Rams. 

Best NFL Week 13 Over/Unders

(Odds via bet365)

GameOver/Under Nov. 28Opening Over/Under Nov. 22
Seahawks vs. Cowboys46 (-110/-110)45.5 (-110/-110)
Colts vs. Titans43 (-110/-110)41 (-110/-110)
Chargers vs. Patriots40.5 (-110/-110)42.5 (-110/-110)
Lions vs. Saints44.5 (-110/-110)44.5 (-110/-110)
Falcons vs. Jets36.5 (-110/-110)36.5 (-110/-110)
Cardinals vs. Steelers40 (-110/-110)39.5 (-110/-110)
Dolphins vs. Commanders50 (-110/-110)49 (-110/-110)
Broncos vs. Texans46.5 (-110/-110)44.5 (-110/-110)
Panthers vs. Buccaneers37 (-110/-110)39 (-110/-110)
Browns vs. Rams39.5 (-110/-110)39 (-110/-110)
49ers vs. Eagles46.5 (-110/-110)45.5 (-110/-110)
Chiefs vs. Packers42 (-110/-110)41.5 (-110/-110)
Bengals vs. Jaguars38.5 (-110/-110)41 (-110/-110)

There are four games with a total still below 40 points in the Week 13 odds, and there are another five above the key range of 43-44. Totals approaching or above 50 have been few and far between the past month of the season due to quarterback injuries and poor play from signal-callers.

NFL betting odds pages

Here are our best NFL betting sites:

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