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The Minnesota Vikings and quarterback Joshua Dobbs are the favorite over the Chicago Bears in the NFL Week 12 odds & betting lines.
Joshua Dobbs of the Minnesota Vikings scores a touchdown against the New Orleans Saints at U.S. Bank Stadium on November 12, 2023 in Minneapolis, Minnesota. Photo by Stephen Maturen Getty Images via AFP.

Here’s our analysis of the NFL Week 12 odds and betting lines from our best NFL betting sites. The three-pack of Thanksgiving games was a great start to the action on Thursday, and the slate features another six divisional games, including the Monday Night Football matchup between the Chicago Bears and Minnesota Vikings. 

While the Week 12 holiday games are in the books, the slate is still loaded with six more divisional matchups, including the NFC North battle between the Chicago Bears and Minnesota Vikings to wrap it all up.

The Buffalo Bills visit the Philadelphia Eagles in Sunday’s marquee clash, and the bout could impact both the Super Bowl odds and the NFL MVP odds.

Here’s a closer look at all of the NFL Week 12 odds from our best sports betting sites.

NFL Week 12 odds and lines

There's an edge to betting NFL odds while trying to beat the closing line. The closer you wait until game time to make your NFL picks, the more difficult it becomes to identify advantages and secure the best number on most side bets or totals.

That's why it's important to start monitoring the NFL opening odds each week as soon as possible. A proactive approach will aid your long-term success.

Best NFL Week 12 spreads

(Odds via Caesars)

GameSpread (Nov. 24)Spread (Nov. 21)Opening spread (Nov. 15)
Patriots vs. GiantsGiants +3Giants +3Giants +5
Panthers vs. TitansTitans -3.5Titans -3.5Titans -4
Jaguars vs. TexansTexans +1.5Texans +1.5Texans +1
Buccaneers vs. ColtsColts -2.5Colts -2.5Colts -1
Saints vs. FalconsFalcons +1.5Pick'emPick'em
Steelers vs. BengalsBengals +1.5Bengals +1Bengals -5.5
Browns vs. BroncosBroncos -1.5Broncos -2.5OTB
Rams vs. CardinalsCardinals +2.5Pick'emCardinals +2.5
Bills vs. EaglesEagles -3Eagles -3Eagles -3.5
Chiefs vs. RaidersRaiders +9Raiders +9Raiders +9.5
Ravens vs. ChargersChargers +3Chargers +3.5Chargers +3.5
Bears vs. VikingsVikings -3Vikings -3.5Vikings -4

There are seven home underdogs remaining in Week 12, and there also aren’t many lopsided spreads left. Just the Kansas City Chiefs are favored by more than a touchdown.

Additionally, there are 10 games left with the margin at or below a field goal. It's shaping up to be a competitive week.

Best NFL Week 12 moneylines

(Odds via DraftKings)

GameMoneyline (Nov. 24)Moneyline (Nov. 21)Opening moneyline (Nov. 15)
Patriots vs. GiantsGiants +150Giants +145Giants +185
Panthers vs. TitansTitans -180Titans -180Titans -192
Jaguars vs. TexansTexans +102Texans +100Texans +100
Buccaneers vs. ColtsColts -142Colts -135Colts -120
Saints vs. FalconsFalcons +105Falcons -108Falcons -110
Steelers vs. BengalsBengals +102Bengals -102Bengals -250
Browns vs. BroncosBroncos -125Broncos -135OTB
Rams vs. CardinalsCardinals +114Cardinals -105Cardinals +110
Bills vs. EaglesEagles -162Eagles -175Eagles -192
Chiefs vs. RaidersRaiders +350Raiders +310Raiders +330
Ravens vs. ChargersChargers +150Chargers +150Chargers +140
Bears vs. VikingsVikings -148Vikings -166Vikings -175

The Chiefs are the largest remaining favorite in Week 12. There’s potential for a lot of minor line movement in the Week 12 moneylines because so many games project to be close.

In addition to the huge movement heading into the Steelers-Bengals game, the New York Giants and Arizona Cardinals both received notable adjustments to their respective moneylines.

Best NFL Week 12 Over/Unders

(Odds via bet365)

GameOver/Unders (Nov. 24)Over/Unders (Nov. 21)Opening Over/Unders (Nov. 15)
Patriots vs. Giants34 (-110/-110)33.5 (-110/-110)35.5 (-110/-110)
Panthers vs. Titans36.5 (-110/-110)37 (-110/-110)38.5 (-110/-110)
Jaguars vs. Texans47.5 (-110/-110)48.5 (-110/-110)45.5 (-110/-110)
Buccaneers vs. Colts44.5 (-110/-110)43.5 (-110/-110)42 (-110/-110)
Saints vs. Falcons41.5 (-110/-110)42 (-110/-110)40.5 (-110/-110)
Steelers vs. Bengals35.5 (-110/-110)34.5 (-110/-110)41.5 (-110/-110)
Browns vs. Broncos36 (-110/-110)35.5 (-110/-110)OTB
Rams vs. Cardinals45 (-110/-110)44.5 (-110/-110)46 (-110/-110)
Bills vs. Eagles48.5 (-110/-110)48.5 (-110/-110)47.5 (-110/-110)
Chiefs vs. Raiders43 (-110/-110)43 (-110/-110)45 (-110/-110)
Ravens vs. Chargers48 (-110/-110)47 (-110/-110)44.5 (-110/-110)
Bears vs. Vikings43 (-110/-110)43 (-110/-110)44.5 (-110/-110)

The opening totals for Week 12 were higher than recent slates, and there were a lot of minor adjustments to the numbers throughout the week. There are four games with a total below 40, while there are another five trading above the key range of 43-44.

NFL betting odds pages

Here are our best NFL betting sites:

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