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The 49ers have been struggling, but several of their key stars are in prime positions to produce against the rival Seahawks.

Underdogs of six or more points are 11-8 SU and 16-2-1 ATS (88.9%) this season, adding even more excitement and intrigue to our Week 6 upset picks.

On the back of an 8-6 Week 5 ATS record, we're back at it in Week 6, looking to improve our 17-13 record in the last two weeks.

Phillip Wood checks out how rookie star Caleb Williams can take advantage of a weak Jacksonville defense as he makes his Jaguars vs. Bears early picks for Week 6's London game.

We dig into if the New York Giants keep upsetting teams when they host the Cincinnati Bengals in Week 6's Sunday Night Football tilt.

We're buying two teams coming off close defeats and fading two teams with questions galore as we look back on NFL Week 5.

We're delivering our NFL survivor picks for Week 6, with an eye toward the sizzling Atlanta Falcons.

The Kansas City Chiefs' Super Bowl odds shortened after the consensus favorites moved to 5-0 with a win on Monday Night Football.

We expect Tyler Huff to huff and puff against one of the nation's worst run defenses in tonight's New Mexico State vs. Jacksonville State.

James Madison is in a perfect bounce-back spot as they face Coastal Carolina at Bridgeforth Stadium on Thursday night.

The winless UTEP Miners have been getting trounced, and that could continue against Western Kentucky.

We're offering our top Middle Tennessee vs. Louisiana Tech prediction for their Week 7 showdown on Thursday, and the home team serves as a 4.5-point favorite.

Alabama's upset loss to Vanderbilt was the highlight of the past week in college football and we're looking at what's in store for Week 7 with our top predictions and picks.

With Alabama losing to Vanderbilt in Week 6, Ohio State is the lone favorite atop the college football championship odds.

With Alabama losing to Vanderbilt, Jalen Milroe is no longer the favorite by the Heisman Trophy odds. Boise State running back Ashton Jeanty now has the top spot.

Following Alabama's loss to Vanderbilt in Week 6, Ohio State and Texas are the only teams with -1000 College Football Playoff odds or shorter.

With a win in Game 3 of the NLDS against the Los Angeles Dodgers, the San Diego Padres are the new favorites by the World Series odds.

Check out our look at the best World Series MVP odds for 2024, with Fernando Tatis Jr. as the betting favorite.

With Shohei Ohtani having put the finishing touches on one of the most incredible seasons in baseball history, we ask baseball fans if he's the best player in the league – and whether he has already earned a spot in the Hall of Fame.

Our Guardians vs. Tigers prediction sees the home team grab a series lead in Game 3 of their American League Division Series.

The New York Mets enter Wednesday with a 2-1 lead over the Philadelphia Phillies in the NLDS, and Mike Spector makes his prediction for who'll win Game 4.

We're offering our top Yankees vs. Royals prediction for Game 3 of the ALDS on Wednesday, with the series tied 1-1 heading back to Kansas City.

Donald Trump is now marginally ahead of Kamala Harris in the U.S. presidential election odds with less than a month remaining until election day.

With election day just over a month away, the Donald Trump presidential election odds show the former president as the favorite again.

Kamala Harris has fallen slightly behind Donald Trump in the latest odds to win the 2024 U.S. presidential election.

The 2024 U.S. presidential election will be decided by electoral college votes. Which states are automatic for each party? And which ones are up for grabs? James Bisson takes a closer look at the current odds and Nate Silver's predictions.

The Montreal Alouettes remain favorites by the Grey Cup odds despite a 37-31 loss to the Toronto Argonauts in Week 17.

Jake "Problem Child" Paul will face "Iron" Mike Tyson in a boxing match on Netflix on November 15 after the initial date was postponed due to a health issue for Tyson.

After winning the NBA Finals last season, the Boston Celtics are the favorites by the 2024 NBA In-Season Tournament odds.

Denver Nuggets center Nikola Jokic is the favorite by the 2025 NBA MVP odds after winning three of the last four awards.

The NBA Rookie of the Year odds are wide open with Grizzlies center Zach Edey holding a slight lead over Rockets guard Reed Sheppard.

Despite Rudy Gobert winning his fourth NBA Defensive Player of the Year award last season, Victor Wembanyama opened as the major favorite to win the award this season.

With Bronny James joining the Los Angeles Lakers to play alongside his father, could LeBron James' son win NBA Rookie of the Year?

What does it take to win a Stanley Cup championship? Goal scoring, grit, goaltending – and enough skating miles to nearly complete a trek from Anchorage to Miami. James Bisson expands in his look at notable NHL EDGE stats from last season.

The Edmonton Oilers are the consensus favorites to win the 2024-25 Stanley Cup, with the Florida Panthers close behind.

Philadelphia Flyers forward Matvei Michkov is the slight favorite by the NHL's Calder Trophy odds for the 2024-25 Rookie of the Year Award, trading just ahead of Macklin Celebrini.

We're analyzing the 2025 Hart Trophy odds, with Connor McDavid the early consensus favorite over Nathan MacKinnon, Auston Matthews, and Jack Hughes.

Igor Shesterkin is the marginal 2024-25 Vezina Trophy odds favorite, trading just ahead of Connor Hellebuyck and Jeremy Swayman.

None of the four teams have complete rosters yet, but Canada is considered the early favorite for the 4 Nations Face-Off.

After winning back-to-back March Madness titles, UConn is the favorite to do it again in 2024-25, followed by Kansas, Duke, and Alabama.

After winning it all in 2024, UConn is among the favorites to advance to a third consecutive Final Four in 2025.

North Carolina's RJ Davis and Kansas' Hunter Dickinson are the Wooden Award co-favorites heading into the season.

After winning the 2024 women's national championship, South Carolina opened as the favorite to win it all again in 2025.

Iowa Hawkeyes star Caitlin Clark won the Women's Wooden Award for a second straight season after being the betting favorite all year.

We're looking at the 2025 Masters odds with Scottie Scheffler as a heavy betting favorite following his second career win at Augusta National Golf Course.

Tracking the best 2025 PGA Championship odds with a look at the favorites and everything to know for Quail Hollow Club in Charlotte, N.C.

Scottie Scheffler, predictably, opened as the betting favorite by the 2025 U.S. Open odds as the year's third major will return to Oakmont Country Club.

Scottie Scheffler is the 2025 British Open betting favorite over Rory McIlroy and Xander Schauffele as the tournament heads back to Royal Portrush in Northern Ireland.

Scottie Scheffler opened as the betting favorite by the 2025 FedEx Cup odds following his first Tour Championship win at East Lake.

Man City are the 2024-25 Champions League odds favorites after two matches, with Real Madrid trading just behind.

Argentina captured a second-straight Copa America title in 2024, and now we're looking ahead to the 2028 version the event.

We don't have odds for Euro 2028 yet, but defending champion Spain are likely to be near the top of the oddsboard, as are back-to-back second-place finishers, England.

France, Spain and Brazil headline the favorites by the World Cup odds for the 2026 tournament in North America.

Spain defeated England in the 2023 Women's World Cup and will attempt to defend its title in 2027.

Alex Pereira is a heavy favorite over Khalil Rountree in the main even of UFC 307, and we break down the action with our UFC predictions.

Check out Andrew Reid's breakdown of the early UFC 307 odds headlined by Alex Pereira vs. Khalil Rountree Jr., taking place Saturday at Delta Center, Salt Lake City.

Check out our top Sean O'Malley vs. Merab Dvalishvili prediction for Saturday's UFC 306 card at the Sphere in Las Vegas.

We have a breakdown of the UFC 306 Noche odds headlined by Sean O'Malley vs. Merab Dvalishvili, taking place Saturday at the Sphere in Las Vegas.

We break down the long-awaited grudge match between middleweight champion Dricus Du Plessis and former kingpin Israel Adesanya.