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Top Serie A Matchday 22 Betting Picks

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Top Serie A Matchday 22 Betting Picks
Inter's Chilean forward Alexis Sanchez celebrates after scoring a goal during the Serie A football match between Salernitana and Inter. Photo by Antonio Balasco/Controluce via AFP.

Serie A leaders Inter Milan will take on title rivals Atalanta in an eagerly anticipated clash this weekend. Heavyweights including AC Milan and Roma are also in action, and we have picks on the biggest games for Serie A’s Matchday 22.

A nine-game win streak in league play has propelled Inter to the top of the table. However, they are just one point clear of a rejuvenated AC Milan, albeit with a game in hand. Napoli and Atalanta lurk ominously behind that duo, so we could be in for an exciting title race in Serie A.

Here are my top betting picks and predictions for the Serie A Matchday 22 schedule (odds via Unibet; pick confidence based on a 1-to-5-star scale).

Serie A Matchday 22 Picks

Lazio -1.25 (-103) vs. Salernitana ★★★
Roma -1.25 (-113) vs. Cagliari ★★★
Atalanta vs. Inter – Both teams to score & Over 2.5 (-121) ★★★

SEE ALSO: Top Premier League Matchday 22 Picks

Serie A Matchday 22 Predictions

Lazio -1.25 (-103)

Salernitana sit at the bottom of the Serie A table with the worst defensive record in the division. They have lost 14 out of 19 games this season, conceding 43 goals in the process.

They have been a little unfortunate, as their expected goals against (xGA) tally is 37.42, but they have undoubtedly struggled to adapt to the rigors of life in the top flight.

Lazio also struggle in defense – only four Serie A teams have conceded more goals than Maurizio Sarri’s men this season – but they also have the fourth-best attacking record in the league.

Lazio beat Salernitana 3-0 in Rome earlier this season, and star striker Ciro Immobile should lead them to another emphatic win this weekend. Salernitana are missing three key defenders due to injury and suspension while holding midfielder Lassana Coulibaly is at the Africa Cup of Nations, which does not augur well for this game.

Roma -1.25 (-113)

Roma blew a 3-1 lead in their 4-3 defeat to Juventus last weekend. That was a disappointing result for manager José Mourinho, but his team should bounce back on Sunday.

Cagliari won their last two games, but they remain in the relegation zone, and their away record is poor. They have lost six out of 10 matches on the road so far this season, and they have conceded 22 goals in those games.

Roma’s best results come at the Stadio Olimpico, but they did beat Cagliari 2-1 away earlier this season. They should secure an even more comfortable victory this weekend, as Cagliari are missing their best two strikers and captain Luca Ceppitelli.

Atalanta-Inter – Both teams to score & Over 2.5 (-121)

It finished 2-2 when these teams met at the San Siro earlier this season. Inter have been on an upward curve since then, and they are now unbeaten since October.

However, Simone Inzaghi’s players could be tired after playing 120 minutes during their 2-1 extra-time victory over Juventus in the Supercoppa Italia on Wednesday.

Atalanta have had the week off, so they will be fresher, and they are coming off a confidence-boosting 6-2 win against Udinese.

These teams have scored more goals than any other clubs in Serie A over the past two years, and they should play out another entertaining clash this weekend.

Serie A Matchday 22 Quick Picks

SEE ALSO: All picks and odds. Be sure to check out's community forums and betting tools.

Serie A Matchday 22 picks made 1/14/2022 at 7:13 a.m. ET.