Top Monday Night Football Prop Picks for Week 10

We have uncovered some intriguing prop picks for the Monday Night Football clash between the Los Angeles Rams and the San Francisco 49ers at Levi's Stadium.

The Rams will bid to return to winning ways when they visit the Niners for the big MNF game in Week 10. They lost to Tennessee last weekend, but remain 7-2 straight up this year and have won all four games on the road.

This game pits one of the league's best teams against one of the most disappointing. The Rams have a great chance of success and there are some interesting prop bets on offer, too.

Here are my top prop picks for the Monday Night Football matchup between the Rams and the 49ers. (Odds via TwinSpires, pick confidence based on a 1-to-5-star scale).

Top Monday Night Football Prop Picks

Rams 1st team to 25 points (-103) ????Matthew Stafford Over 283.5 passing yards (-114) ????Elijah Mitchell Under 63.5 rushing yards (-113) ???

SEE ALSO: Rams vs. 49ers Week 10 Picks

Monday Night Football Prop Bets

Rams 1st team to 25 points (-103)

It is easy to see the Rams putting up at least 25 points against San Francisco in this game. The Niners have allowed more than 25 points in five out of eight games so far this season and they are coming off a 31-17 defeat at the hands of the Arizona Cardinals.

The San Francisco secondary is very weak, so Rams star Cooper Kupp and new acquisition Odell Beckham Jr. could run riot in this game. Quarterback Matthew Stafford struggled last week, but he will be keen to make amends and he should inspire his team to victory.

The Rams have scored more than 25 points in seven of their nine games so far this season. The 49ers have only hit that total three times and they look unlikely to do so against a Rams defense that has only allowed 25 points twice this year.

Stafford Over 283.5 passing yards (-114)

Stafford is third in the NFL in passing yards per game this season, with 307.9. Only Derek Carr and Tom Brady can beat that average. He has flourished in coach Sean McVay's offense and he even threw for 294 yards in a disappointing performance against Tennessee in Week 9.

Stafford is averaging more than 35 throws per game and the Rams are unlikely to run the ball too much on Monday, which should give Stafford lots of opportunities to exploit San Francisco's weak secondary.

Mitchell Under 63.5 rushing yards (-113) ???

The prevailing logic is that the Niners will give the ball to Mitchell as much as possible in a bid to slow things down and restrict McVay's offense.

He has certainly been the Niners' most effective weapon this season, smashing through the 100-yard barrier in three different games. However, the excitement surrounding Mitchell has pushed the line up from 61.5 yards to 63.5 yards, representing an interesting opportunity to fade the public.

Mitchell mustered just 36 yards off eight carries against Arizona last week as the Niners fell behind and had to abandon the run game. A similar scenario could play out on Monday.

Combined odds: Rams 1st to 25 points (-103) + Stafford Over pass yards (-114) + Mitchell Under rush yards(-113) = +596

Picks made on 11/14/2021 at 10:23 a.m. ET