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Top 10 Matchups to Spot on your Calendar for the 2020 NFL Regular Season

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The Kansas City Chiefs celebrate on the podium after winning Super Bowl LIV between the Kansas City Chiefs and the San Francisco 49ers at Hard Rock Stadium in Miami Gardens, Florida, on February 2, 2020. (Photo by Angela Weiss / AFP)

What are the must-see matchups in the 2020 NFL Regular season? Find out where we shine the spotlight on the hot-off-the-press NFL schedule.

The NFL schedule is finally here and it’s littered with a veritable feast of must-see matchups that we simply can’t wait to see. Super Bowl contenders, dangerous floaters, top star players, scintillating rivalries, veterans going head-to-head and 2019 rematches are just some of the many storylines providing a compelling backdrop against which these games will play out.

Here are some of the matchups that we’ve earmarked as the best contests promising to deliver some of the season’s most memorable action.

NFL Week 1

Houston Texans vs. Kansas City Chiefs

Thursday, September 10, 8:20 PM EST

Arrowhead Stadium, Kansas City TV
Broadcast: NBC

The Texans and Chiefs collided twice last season and split the results but the Chiefs won the most important game of all. By all accounts, the Chiefs pulled off an extraordinary, come-from-behind win over the Texans in the AFC Divisional Round of the playoffs, what in hindsight was the springboard to Patrick Mahomes’ sensational march to Super Bowl LIV victory.

Right out of the gates, on Thursday Night Football to kick off the season, the defending champions, who are tipped as the team to beat in SBLV betting markets (best price of +750 with BetOnline) will be tested. It’s going to be interesting to see this intriguing AFC showdown unfold. While the Chiefs remained largely intact on offense – adding more clout and weapons in the offseason for Patrick Mahomes to play with – Bill O’Brien has taken a hammer to Deshaun Watson’s supporting cast on offense, most notable sending DeAndre Hopkins packing.

Drew Brees #9 of the New Orleans Saints. Chris Graythen/Getty Images/AFP

Tampa Bay Buccaneers vs. New Orleans

Saints Sunday, September 13, 4:25 PM EST

Mercedes-Benz Superdome, New Orleans
TV Broadcast: FOX

Does this matchup really need any preamble? Two words: TWO GOATs. Tom Brady in his first game as a Buccaneer, taking on Drew Brees – to a larger extent, two veteran 40-something, future Hall of Fame quarterbacks battling – in an NFC South showdown. That’s the first of at least two certain matchups – excluding a potential playoff date – is set to get underway in the first week of the NFL season only underscores the NFC South’s odds, in which the Saints and Bucs are neck-and-neck for divisional honors.

Week 3

Kansas City Chiefs vs. Baltimore Ravens

Monday, September 28, 2020, 8:15 PM EST

M&T Bank Stadium, Baltimore
TV Broadcast: ESPN

Two of the most fascinating young quarterbacks in the league reprising their rivalry in the third week of the NFL season in primetime is undoubtedly a must-see, pop-corn matchup. How can one not be excited to see this game unfold, if only to learn whether the pair lives up to their top billing in Super Bowl LV betting markets. The Ravens are nipping at Chiefs’ heels as the second-best bet, best priced at +800 with BetOnline and SportsBetting.

Green Bay Packers
Quarterback Aaron Rodgers #12 of the Green Bay Packer. Dylan Buell/Getty Images/AFP

Week 6

Green Bay Packers vs. Tampa Bay Buccaneers

Sunday, October 18, 4:25 PM EST

Raymond James Stadium, Tampa
TV Broadcast: FOX

Given the length of the careers of both Aaron Rodgers and Tom Brady, it’s somewhat surprising to learn that the pair have only met three times. Simply from a sentimental viewpoint, the superstar meeting is definitely one for the history books. Unless, Rodgers – for some inexplicable or unforeseen reason – doesn’t start this game and instead rookie Jordan Love is the offensive pivot. Green Bay has downplayed the decision to trade up and draft the Utah State quarterback but what if that’s just smoke and mirrors. And there’s more to the decision than they’re not letting on. Heady thoughts indeed.

Week 9

Green Bay Packers vs. San Francisco 49ers

Thursday, November 5, 8:20 PM EST

Levi Stadium, Santa Clara
TV Broadcast: FOX/NFL

San Francisco 49ers practically owned the Green Bay Packers last season, twice dealing Aaron Rodgers arguably the worst couple of (if not, THE worst) losses of his career. This could be the craziest Thursday Night Football showdown of the season. If it unfolds as it did last season can Matt LaFleur justifiably leave Jordan Love on the bench? BetOnline is offering a prop bet on Jordan Love, pricing the rookie quarterback at +3000 to win offensive rookie of the year honors.

Quarterback Jordan Love of Utah State throws a pass during the NFL Scouting Combine at Lucas Oil Stadium on February 27, 2020 in Indianapolis, Indiana. Joe Robbins/Getty Images/AFP

Week 10

San Francisco 49ers vs. New Orleans Saints

Sunday, November 15, 4:25 PM EST

Mercedes-Benz Superdome, New Orleans
TV Broadcast: FOX

Every season there is a marquee matchup that goes down as a right cracker, an offensive doozie that leaves fans utterly speechless. This matchup was exactly that last season, a 48-46 shootout in the Superdome.

It had everything. Back-and-forth action as both sides traded leads, a bucketload of touchdowns from both Drew Brees and Jimmy Garoppolo – heck, even Emmanuel Sanders threw a 35-yard touchdown pass – and a nerve-biting, thrilling finish on a last-gasp push by the Niners. Circle this one for week 10 because it’s sure to be another memorable showdown by two of the top favorites in NFC Conference betting markets.

Week 12

Kansas City Chiefs vs. Tampa Bay Buccaneers

Sunday, November 29, 2020, 4:25 PM EST

Raymond James Stadium Tampa
TV Broadcast: CBS

Patrick Mahomes led the Chiefs to a keynote victory over Tom Brady and the Patriots at the Foxboro last season, recording his first-ever win over the GOAT. The matchup may be slightly different but the quarterback star power remains the same. This time, TB12 will have Rob Gronkowski and a slew of exciting receivers to go toe-to-toe with Mahomes.

How can Brady, Mahomes, Gronk and Travis Kelce on the same field, along with the coaching genius of both Andy Reid and Bruce Arians emanating from the side-lines, not be must-see TV. If the Bucs are really as good as their preseason hype suggests they are, this may well be a Super Bowl preview game.

Tom Brady #12 and Rob Gronkowski #87 of the New England Patriots. Adam Glanzman/Getty Images/AFP

Week 13

Dallas Cowboys vs. Baltimore Ravens

Thursday, December 3, 2020, 8:20 PM EST

M&T Bank Stadium, Baltimore
TV Broadcast: FOX/NFL

Dallas Cowboys represent TV-ratings currency, not for nothing are they widely considered as America’s team. Can the emerging star Lamar Jackson, last season’s runaway MVP, repeat his 2019 season? Will Dak Prescott measure up in Mike McCarthy’s new-look Cowboys? Or, will Dak even be the starter when this matchup comes around. Might Andy Dalton feature instead in this game, which would mark a reunion for the red rifle with his former AFC North rivals. BetOnline serves up Dalton at +3300 odds for the proposition bet, ‘NFL 2020 Comeback Player of the Year.’

Week 15

Kansas City Chiefs vs. New Orleans Saints

Sunday, December 20, 2020, 4:25 PM

Mercedes-Benz Superdome, New Orleans
TV Broadcast: CBS

For the last few seasons, the New Orleans Saints have been dubbed legitimate Super Bowl contenders. Two years ago, they were cruelly denied a trip to Super Bowl 53 in the NFC Championship game. Last season, they were stunned by the Vikings in the NFC Wild Card round.

Most top-rated sportsbooks have this matchup among some of the top Lombardy-worthy contests this season. As such, the week 15 contest between this pair could serve as a handy preview for the playoffs, with Mahomes and Brees taking the measure of one another. This has the makings of another pass-happy, offensive thriller, not unlike the 49ers vs Saints last season or the Chiefs vs Rams two years ago. Get the popcorn at the ready!

San Francisco 49ers defensive coordinator Robert Salah. Lachlan Cunningham/Getty Images/AFP

Week 17

Seattle Seahawks vs. San Francisco 49ers

Sunday, January 3, 2021, 4:25 PM EST

EST Levi Stadium, Santa Clara
TV Broadcast: FOX

No game was more pivotal, deciding or, for that matter, thrilling than the final game of the 2019 season between these NFC West rivals. It came down to the final seconds and a goal-line stand by the Niners, summing up the awesomeness of Robert Salah’s defense that navigated the Niners’ course through the regular season. Moreover, it delivered the top seed to the Niners and, by that same token, sent the Seahawks into the wildcard round.

Going into 2020, the Niners are the clear-cut favorites to repeat as NFC West champions but the Seahawks are legitimate dangerous floaters that could challenge for divisional bragging rights. That this game is set to drop the curtain on the regular season is fitting. And if both the Niners and Seahawks live up to their preseason hype, then this contest is bound to be decisive once again.