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Kenneth Walker of the Seattle Seahawks runs the ball as we share our favorite Panthers vs. Seahawks prediction.
Kenneth Walker of the Seattle Seahawks runs the ball against the Detroit Lions at Ford Field on Sept. 17, 2023 in Detroit, Michigan. Photo by Nic Antaya/Getty Images via AFP.

Here are our top Panthers-Seahawks predictions rooted in the best NFL odds from our best sports betting apps. Seattle lost its first home game, so can quarterback Geno Smith even their record at Lumen Field while lighting up the winless Panthers?

The Seattle Seahawks went into Ford Field and turned in a statement overtime win against the Detroit Lions. Seattle quarterback Geno Smith flashed the same form that made him the Comeback Player of the Year last year with 328 passing yards and two touchdowns.

The winless Carolina Panthers will be without rookie QB Bryce Young due to an ankle injury, so veteran Andy Dalton will step in. Points have hard to come by for Carolina, so it could prove tough for the ‘Red Rifle’ and his mediocre supporting cast to pull off the upset in Seattle.

As part of our NFL best bets for Week 3 and NFL week 3 predictions, here is our best Panthers vs. Seahawks prediction and NFL picks (odds via our best NFL betting sites; pick confidence based on a 1-to-5-star scale).

Panthers vs. Seahawks prediction

Seahawks -5.5 (-105 via FanDuel) ⭐⭐⭐⭐

The Carolina Panthers started 0-2 while scoring under 20 points in each game for the first time since 2010 when they started 0-5 and failed to record 20 points in each of those matchups. Meanwhile, the Seahawks scored at least 20 points in all five regular-season home meetings against Carolina.

Young is the first player this century to record 160 or fewer passing yards and at least 30 attempts in each of his first two NFL starts, and he's likely to miss this game due to injury. Whether it's Young or Dalton under center, either faces a challenge against Seattle’s defense. The Seahawks' D forced negative yardage on 10 opponent rush attempts this season, an NFL-most. Seattle also allowed 2.45 yards per rush on first down in 2023, a league-lowest. 

If Carolina relies on its backs to support the QB, it'll have a hard job moving the ball. Seattle’s O-line should withstand an injured Panthers' defensive front. Expect a solid ground game from Seahawks running back Kenneth Walker III, who rushed for two TDs last week, along with a choice of top-class receivers at Smith’s disposal.

It's a long trip for the Panthers, who field the weaker roster. The spread is less than a touchdown, so expect Seattle to cover.  

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Panthers vs. Seahawks best odds

FanDuel (-105)

-5.5 -5.5 -5.5 -5.5 -5.5

The Seahawks began as 4-point favorites, and that moved as high as -6.5 with some of our best sports betting apps. At the start of Friday, four of our best sports betting sites had the line at -6, but that dropped to -5.5. This might be because Dalton is likely to be the starter against Carolina. Panthers rusher Miles Sanders’ health status was also upgraded from questionable to healthy.

Carolina linebacker Shaq Thompson is out for the year, and cornerback Jaycee Horn is a big loss in the Panthers’ secondary with Hawks' wideouts D.K. Metcalf and Tyler Lockett bearing down on them. This could be a mismatch in quality and depth. 5.5 points is a good line for Seattle, who looks for its first home win of the season.

Panthers vs. Seahawks odds

Panthers vs. Seahawks odds analysis

The total was set at 42.5 points at DraftKings. With Carolina’s offensive struggles, bet on the Under. If the Seahawks take an early lead, they could run the clock with their ground game.

Caesars has Seattle -240 SU. Get +196 for Carolina on the moneyline at the same sportsbook.

Panthers vs. Seahawks game info

  • When: Sunday, Sept. 24 at 4:05 p.m. ET
  • Where: Lumen Field, Seattle, WA
  • How to watch: CBS
  • Weather: 59 degrees, 35% chance of precipitation, 5-mph winds

Panthers-Seahawks prediction made Friday, 9/22/23 at 1:37 p.m. ET

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