NFL Week 6 Predictions - San Francisco 49ers vs Buffalo Bills Odds & Free Picks

Buffalo Bills  players celebrating

Ross Benjamin

Tuesday, October 11, 2016 3:45 PM GMT

Our sports handicapping professional went 2-1 with his NFL picks this past Sunday and is now 9-5 (64.3%) over the previous 3 weeks. Join us in reading his betting preview on Sunday’s upcoming game between San Francisco and Buffalo. 

 

San Francisco 49ers vs Buffalo Bills  

Buffalo will host San Francisco in a non-conference game on Sunday. The opening kickoff at New Era Field is slated for 1:00 PM ET. The last time these teams met was in 2012, and San Francisco came away with a decisive 45-3 home win.

 

49ers Road Woes and Current Losing Streak

San Francisco has struggled mightily in recent away games. As a matter of fact, they’ve gone 1-11 during their previous 12 road contests, and were also a pathetic 2-11 ATS in those games. During their last 10 road tilts, the 49ers allowed a lofty average of 33.5 points per game. San Francisco is 0-2 SU&ATS in the away game this season. They allowed 41.5 points and 473.5 yards per game during those pair of defeats.

After opening the season with a dominating 28-0 home win over Los Angeles, San Francisco has preceded to go 0-4 SU&ATS since that time, and lost by a sizable average of 14.3 points per game.

 

Bills Regain a Pulse

Following a Thursday night home loss to the Jets, Buffalo was 0-2 just 5 days into the season. As you can well imagine, it was all doom and gloom in Western New York for their loyal fan base. After all, they’ve suffered through 16 straight seasons of not making the playoffs. However, the Bills have bounced back to go 3-0 SU&ATS during their next 3 contests, and won by an impressive average of 14.0 points per game. Keep in mind, 2 of those victories came as an underdog against Arizona and New England. The other came just this past Sunday as a 2.5-point favorite at Los Angeles, and occurred against a Rams team that was riding a 3-game win streak of their own.

Throughout this current 3-game win streak, Buffalo has rushed for a combined 535 yards, and averaged an inspiring 5.9 yards per running attempt. Furthermore, the Bills defense has allowed a paltry 12.3 points and recorded 4 sacks per contest during that precise time period.

 

NFL Odds, Betting Angle & Pick

At the time of this writing, NFL betting odds at BetOnline indicated that Buffalo was a 7.5-point favorite. BetOnline is presently offering 50% cash bonuses for all new customer signups.

Buffalo hasn’t committed a turnover in each of their last 2 games. San Francisco had a -3 turnover margin in their previous game. The aforementioned statistical data sets up a very profitable betting algorithm, and one that I’ll take full advantage of when making this week’s NFL picks.

Any NFL favorite of 3.5 to 10.0 (Buffalo) that committed 1 turnover or less during their previous game, versus an opponent (San Francisco) that possessed a -3 or worse turnover margin in its last contest, resulted in those home favorites going 52-22 ATS (70.3%) since 2007. The favorite’s average line in those 74 contests was -6.6, and they had a +12.1 point per game differential.

 Free NFL Pick: Buffalo Bills -7.5
Best Line Offered: at BetOnline

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