NFL Picks: New England Patriots vs. Buffalo Bills Week 2

David Lawrence

Friday, September 18, 2015 3:24 PM GMT

One of the best games of the week could come from the AFC East, as the Patriots and BIlls meet in Week 2. Read on for our full game preview and free NFL picks for what looks to be an exciting battle.

After one of the great pre-game ceremonies ever done by a Super Bowl champion, New England handled Pittsburgh 28-21 at home behind four touchdowns from Tom Brady – three of which went to Rob Gronkowski. However, Buffalo's 27-14 win over Indianapolis at home might have been the best performance of the weekend as the Bills smothered Andrew Luck. Given Rex Ryan's history with New England counterpart Bill Belichick and the Patriots from his time in charge of the New York Jets, this is must-see TV.

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Opening Odds & Line Movement
Open: PK -110 at Pinnacle

This NFL odds started out as a pick 'em and has now slid to -1 for the Patriots on the road, which was to be expected given that they're the defending Super Bowl champions and what they did last week in the face of Brady's suspension being lifted; they all but danced in the office of Roger Goodell (who didn't go to New England). But that is only -1 for New England is a credit to how well Buffalo played last week, namely the defense and quarterback Tyrod Taylor, who wasn't given a lot to do, but he managed the game very well.

 

Injuries
The Patriots probably won't have defensive lineman Dominique Easley for at least another couple weeks due to a hip pointer, while on the other line, Ryan Wendell is limited due to illness, but as always for the Patriots, it's next man up and no team in the NFL does it better.

Buffalo has more to worry about as LeSean McCoy is questionable with a hamstring injury and even though Karlos Williams had 55 yards and a touchdown on just six carries (while Taylor added 41, the same amount as McCoy), McCoy is the one who got the giant contract in the offseason and the Bills want him on the field. Percy Harvin's hip shouldn't stop him from playing this week, but Sammy Watkins' hamstring is a worry.

 

Trends
The Patriots are just 2-3-1 ATS in their last six overall, and they're 1-5 ATS in their last six AFC East games as their division rivals usually get up to play the big, bad Pats. They're 5-1 SU and 4-2 ATS in their last six on the road, while Buffalo is 5-1 SU and 4-1 ATS in their last six at home. The total of 45 dropped from 45.5, and could even more as the Patriots have gone under in seven of their last 10, while the Bills have done the same in eight of their last nine.

The Bills are just 2-8 SU in their last 10 against New England, although they've covered in half of those games. In Buffalo, the Patriots have gone a staggering 9-1 SU and 7-2-1 ATS in their last 10 trips, but people making their NFL picks seem to feel that this is a different Buffalo team that will be looking to make a statement on Sunday.