Arizona moved to 4-1 with a destruction of Detroit on the road, scoring 40-plus points for the third time this season. Pittsburgh is now 3-2 after a huge last-second win in San Diego on Monday night.
Opening Odds & Line Movement
Open: -3 -110 at Pinnacle
The Cardinals opened as a field-goal favorite on the road and that is where the NFL odds continues to stay, which is fair considering how Arizona has played so far this year. Outside of their loss to St. Louis, the Cardinals have been lights out, beating teams by an average of over 25 points a game, but then you have the loss to the Rams; that's enough to put a little doubt out there. The Steelers beat those same Rams, on the road no less, and they're a veteran team that has been getting by without Ben Roethlisberger. They're not afraid of anyone or anything, and Heinz Field is going to be loud on Sunday.
S Chris Clemons is now out for the season because of his hamstring, while fellow S Tyrann Mathieu didn't practice on Wednesday because of his heel. The Cardinals haven't ruled him out yet, though, so keep an eye on that. Arizona's defense has been overshadowed by their offense as they rank ninth in the NFL in yards allowed, and the return of Mathieu has been a big part of that.
S Will Allen had to leave the San Diego game with an ankle injury, but he is the only new injury for Pittsburgh. There was a little speculation about Roethlisberger returning this week from his knee injury as he has been taking part in 7-on-7 drills, but playing on a short week would be a slight miracle for him.
Arizona is 4-1 ATS in their last five games overall, and they've gone over in all five of those games as well; they also have a 4-1 ATS mark in their last five on the road. The Steelers are 7-1-2 ATS in their last 10, and 6-2-1 ATS in their last nine at home. They've gone under in four of their last five games.
The Steelers are 4-1 SU and 3-2 ATS in their last five meetings with Arizona, which includes their win at Super Bowl XLIII. The Cardinals are 0-2 SU and ATS in two trips to Pittsburgh.
***Follow the link to get all of the Week 6 NFL picks!***