49ers vs. Cardinals Week 3 Betting Preview & NFL Picks

David Lawrence

Saturday, September 26, 2015 4:20 PM GMT

Saturday, Sep. 26, 2015 4:20 PM GMT

San Francisco had one of the wildest offseasons in recent memory, but they shocked everyone in their thumping of Minnesota in Week 2. However, they crashed back to earth in Pittsburgh and now the 49ers have to get back on track quickly before heading to Arizona, who have scored 79 points in wins over New Orleans and in Chicago. A win here would keep the Cardinals in first in the NFC West, but the 49ers won't want to go down without a fight.

Opening Odds & Line Movement
Open: -6.5 -105 at Pinnacle
The Cardinals opened as 6.5-point favorites at home before the NFL odds shifted to -6, then moved back to -6.5. That is a fair line considering how good the Arizona offense has looked, especially QB Carson Palmer. The Cardinals' season went down the drain last year when Palmer got hurt, but he has returned to throw seven touchdowns and a single pick over the first two games of the season and he is third in the league in QB rating, while the San Francisco defense is 26th against the pass, so keep that in mind.

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Injuries
The 49ers could be without RB Reggie Bush, who is still bothered by a calf injury and didn't practice on Wednesday. Neither did LB NaVorro Bowman, but you can expect that for much of the season after he missed all of last season with a knee injury. Considering what the 49ers lost in the offseason at LB, they want to keep Bowman healthy and fresh.

G Mike Iupati was drafted by the 49ers in 2010, but left in March for Arizona and hasn't been able to play because of a knee injury, but he should make his debut this week. LB LaMarr Woodley has a bad shoulder that has him as questionable, while RB Andre Ellington is a doubt because of his knee.

 

Trends
The 49ers have covered the betting spread in just one of their last eight games, while the Cardinals have done so in 11 of their last 15, including seven of eight at home. The 49ers are 2-4 SU and ATS in their last six on the road. For the total, San Francisco has gone under in seven of their last nine, while the Cardinals have gone over in four of their last five; this total is set at 43.5.

The Cardinals are 2-8 SU in their last 10 meetings with the 49ers, covering in four games. At home, Arizona have split their last 10 against San Francisco, and have covered in just three games.

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