The Citizens are quoted at 4/5 to get the win on Sunday, while the visiting Reds can be locked down at a price of 33/10. A draw has to be strongly considered with your Premier League picks too, with that wager currently listed at 14/5.
After all, these two teams did tie 2-2 back in late August in their first Premier League encounter against one another. Luis Suarez and Martin Skrtel scored for Liverpool, while Yaya Toure and Carlos Tevez got on the score-sheet for City in the deadlock at Anfield.
Be sure to check out our Premier League Tips & Picks: Weekend Rundown for insight on all of the upcoming EPL fixtures.
The Citizens failed to capitalize on a number of chances in a midweek 0-0 draw against QPR. It was a disappointing day at the office, though the performance of Rangers goalkeeper Julio Cesar was outstanding.
As a result, City is now seven points back of Manchester United for the top spot in the table. With the Red Devils set to face Fulham away from home this weekend, the Citizens may have another chance to gain some ground should United have trouble.
Still, that's assuming it's going to be a walk in the park for Mancini's men versus Liverpool, and we don't believe that's what Sunday's fixture will be for the hosts.
A lot of the headlines have been on Mario Balotelli's departure to AC Milan. We have to say we're a bit upset to see the enigmatic (and fascinating) Balotelli leave the Premier League, but it was the right move for both parties. Things were simply not working out for the Italian over in Manchester, especially this season.
Truth is, Balotelli was stuck behind Sergio Aguero, Carlos Tevez and Edin Dzeko in the pecking order up front. He'll have many more opportunities to show his worth in Milan.
Days after a shock 3-2 loss to Oldham Athletic in the FA Cup, the Reds put up a much better fight in a 2-2 away draw against Arsenal.
Liverpool had raced out to a 2-0 lead behind goals from Luis Suarez and Jordan Henderson, but then some shoddy defending was their demise in the second half. The Reds poorly defended a set piece, leading to an Olivier Giroud header, and then Theo Walcott blasted home from inside the box just a few minutes later.
While surrendering a lead is hard to take, Liverpool had to be satisfied with a point from this fixture from a general perspective.
That's especially true since a host of the other clubs in the race for the top four also failed to grab three points during the week. Chelsea, Tottenham and Swansea City all picked up just a point as well, with Everton the only side to really take advantage with a victory over West Brom.
Liverpool will now face another difficult test away from Merseyside, but there's a chance we'll see Coutinho, a recent signing from Inter, make his debut. And don't forget about the havoc Suarez can cause – he's already scored 17 league goals this term.
Premier League Pick
The Reds tend to give City a run for their money and we believe they'll do so yet again on Sunday.
Though the Citizens have still been excellent for the most part at home, they've proven to be beatable a the same time. Liverpool seems to be playing much better domestically these days and we think Rodgers' outfit will have enough to at least get a point.
Therefore I believe that the best option for our sports picks is on a draw at 14/5 in the football odds.
Premier League Pick: Manchester City 1 Liverpool 1