According to the sportsbooks, this Group A clash should be the tightest of the three matches that will take place on Friday.
Mexico is the favorite at right around +125, with Cameroon at +250 to +300 and a draw quoted at +220.
Unlike many of the other World Cup participants, Mexico has been quite active in recent months, playing a total of six friendlies since early March.
They've had mixed results. Wins over Israel (3-0) and Ecuador (3-1) were impressive, while a 2-2 away draw against the United States was more than respectable, but they lost to both Bosnia and Portugal by a 1-0 score-line and also tied Nigeria (0-0) at home.
Still, Mexico has suffered through quite a bit of turmoil and turnover and it does appear they're at last starting to find some cohesion to their play.
The most recognized players on the squad include Manchester United striker Javier Hernandez, who has 35 goals in 62 international appearances, as well as long-serving members like Carlos Salcido (122 total caps), Rafael Marquez, Andres Guadardo and Giovani dos Santos.
We're eager to see what kind of impact Mexico, ranked #19 in the FIFA rankings, will have on this tournament. They have the individual talent to make some noise, but will it all come together?
The Cameroonians have played four friendlies since late Mary, beating Macedonia (2-0) and Moldova (1-0), drawing with Germany (2-2) and losing to Paraguay (1-2).
That's quite a good run of results there, particularly that deadlock (away from home no less) with a German outfit that was near full strength. Samuel Eto'o and Maxim Choupo-Moting scored the goals in the draw.
We know Eto'o is the heartbeat of this Cameroon squad, as he's made 117 appearances, almost double the number of anyone else on the team, while scoring 56 goals at the international level. He scored some crucial goals for Chelsea this past season and that should have him confident as ever for the World Cup campaign.
We're also looking forward to watching the likes of Choupo-Moting, who's been averaging almost a goal every other game for the national team, as well as well-known players like Alex Song and Stephane Mbia trying to control the midfield.
The big question mark revolves around the defense, which doesn't have a ton of experience at the highest level. Can they rise to the occasion in a tough group that features Brazil, Croatia and of course the Mexicans?
World Cup Pick
It's never easy forecasting the opening matches in a World Cup, as we've yet to really what these teams are capable of at full strength and with everything to play for.
But, when push comes to shove, we do think Cameroon will put up a better fight than many might expect.
There's a good deal of experience within the squad, at least in the midfield and attack, and it certainly helps that their captain is a savvy goalscorer who needs very little time and space to find the back of the net. We're predicting a draw at the end of the day, a result that would probably satisfy both teams here on Friday.
World Cup Pick: Mexico 1 Cameroon 1