Let’s take a closer at the MLB betting odds for this American League West matchup at Safeco Field, with the first pitch scheduled for 10:10 p.m. ET.
Playing better on the road
Los Angeles won three of four games against the Houston Astros in its first road series, including a 9-1 victory as -155 favorites Monday, while going OVER the betting total for the sixth time in seven contests.
Dating back to last season, Angels outfielder Josh Hamilton has hits in 20 of his last 21 games—a big part in why he was named co-AL Player of the Week Monday.
Over the last two-plus seasons, the franchise is 21-20 as road underdogs of +100 to +125, with the OVER going 26-14-1 in that situation.
Back in the Pacific Northwest
Seattle is ready for its home opener after enjoying a day off and completing a 4-2 road trip, but the squad suffered a 6-3 defeat to the Oakland Athletics as +131 underdogs last time out.
The Mariners were 6-4 against the Angels at this ballpark during the 2013 campaign, while the OVER is on a 4-1 run in the overall series.
MLB handicappers will find that the club is 28-9 at home with a money line of -100 to -125 in its last 37 opportunities.
Angels starting pitcher Hector Santiago (0-1, 7.20 ERA) suffered a 8-2 home loss to the Mariners last week, as he surrendered four runs and seven hits over five innings of work.
The left-hander has compiled a 0-3 record and 4.91 ERA in 15 career appearances in April, with opposing hitters batting .301 against him.
In 20 road appearances (12 starts) last season, Santiago went 3-5 with a 3.12 ERA.
Mariners starting pitcher James Paxton (1-0, 0.00 ERA) picked up a win versus Sanchez in his season-opening effort—allowing two hits over seven shutout frames.
The left-hander has gone 4-0 with a 1.16 ERA in five career starts as a professional, including a 3-0 mark and 1.50 ERA in four efforts in 2013.
I’m going to recommend that readers back the Mariners as one of their MLB picks, as I established them as -135 home favorites in this affair.
Los Angeles will drop its fifth consecutive game as a road underdog dating back to last season.MLB Pick: Seattle Mariners -122