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Giants vs. Yankees Predictions, Picks & Odds: Can New York Establish Dominance on Opening Day?

Neil Parker

Last Updated: March 30, 2023 10:57 AM EDT • 2 min 40 sec read.

Gerrit Cole with start Opening Day as we look at our best Giants vs. Yankees prediction.
Gerrit Cole of the New York Yankees reacts after a strikeout against the Cleveland Guardians during the seventh inning in game four of the American League Division Series. Photo by Christian Petersen/Getty Images/AFP.

Opening Day has finally arrived, and the championship-hopeful New York Yankees send Cy Young favorite Gerrit Cole to the bump against the pesky San Francisco Giants on Thursday afternoon at Yankee Stadium. Sportsbook Review betting analyst Neil Parker's offers his top Giants vs. Yankees prediction based on the MLB odds from our best sportsbooks.

This will be the fourth consecutive Opening Day start for the New York ace, and Cole's also the reigning MLB strikeout-leader. The imposing righty is coming off a solid string of spring starts with 27 strikeouts and a 3.32 ERA across 21 1/3 innings over his five outings.

Giants starter Logan Webb wasn’t as effective in exhibition action. 

He posted a run-of-the-mill 4.50 ERA and 1.61 WHIP through 18 frames over his five starts, but Webb will look to turn the tide in his second consecutive Opening Day start for San Fran.

Here is our best Giants vs. Yankees prediction (odds via FanDuel Sportsbook; pick confidence based on a 1-to-5-star scale).

Giants vs. Yankees odds

Giants vs. Yankees game info

  • Date: Thursday, March 30, 1:05 p.m. ET
  • TV: MLB Network, YES Network, NBC Sports Bay Area
  • Location: Yankee Stadium, New York City, NY
  • Weather: 42 degrees, 0% precipitation, 12.8 mph winds to right

Giants vs. Yankees prediction

Yankees race to 3 runs (-105 via FanDuel) ⭐⭐⭐

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It’s going to be a touch chilly Thursday afternoon in the Bronx, and I’m not expecting the Giants to put many runs on the board. Cole tossed 5 2/3 innings in his final spring tuneup, and the American League Cy Young favorite limiting the ho-hum San Fran lineup shouldn't surprise anyone.

The Giants posted a middling 99 wRC+ and .308 wOBA while striking out 23.5% of the time against righties last season, and I expect them to trot out a worse offense this season. 

New York has a deeper and more potent lineup, and the Yankees also scored the third-most runs (5.2) in baseball at home last season. 

It’s also notable that Webb hasn’t been as sharp on the road during his career. The 26-year-old righty sports a career 3.01 ERA and 2.67 FIP at pitcher-friendly Oracle Park, but those marks respectively climb to 3.95 and 3.67 on the highway.

Giants vs. Yankees best odds

FanDuel (-105)

DraftKingsFanDuelBetMGMCaesarsPointsBet
NYY race to 3 runsNYY race to 3 runsNYY race to 3 runsNYY race to 3 runsNYY race to 3 runs
-125-105N/A-118-115

I’ve graded this with a three-star nod because it’s Opening Day, and while I’m encouraged by Cole’s form this spring, it doesn’t mean it’s going to immediately translate to the regular season.

Originally, I billed this as a two-star recommendation. However, FanDuel moved the odds from -132 to -105, and there’s now a decent edge compared to the -125 number via DraftKings. It checks out as a positive expected value of 9%.

Giants vs. Yankees odds analysis

DraftKings opened the moneyline for this game with the Giants listed at +145 and the Yankees at -170. There was quick movement to the NY side with the two teams respectively trading at +160 and -190 as of Thursday morning. New York has also taken 77% of the moneyline action, according to our matchup page.

The total ranges from 7.5 through DraftKings, BetMGM, Caesars and PointsBet while FanDuel posted the number at 7. According to our matchup page, 54% of the betting action has been on the Over.

Giants-Yankees pick updated 3/30/2023 at 8:45 a.m. ET.

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Written By:
Neil Parker
A lifelong Cowboys, Cubs, Maple Leafs and Gators supporter, Neil has been covering sports in print and online since 2011. His past stops include USA TODAY, theScore, DraftKings Playbook and RotoWire among others. He's a graduate of St. Thomas University and Acadia University and spends ample time at KenWo Golf Club.