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Titus Swen of the Wyoming Cowboys drops a pass from Andre Peasley during the first half of their game against the Brigham Young Cougars.
Titus Swen of the Wyoming Cowboys drops a pass from Andre Peasley during the first half of their game against the Brigham Young Cougars. Chris Gardner/Getty Images/AFP.

The Wyoming Cowboys and Fresno State Bulldogs do battle in the final game of college football's 13-game Week 13 slate following Thanksgiving Day. Read on as we offer up our top Wyoming-Fresno State college football picks.

Fresno State has been busy rattling off six consecutive wins after starting the season 1-4, earning the West Division title in the Mountain West and a spot in the championship game. The Bulldogs are heavily favored in Week 13 over a Wyoming team that's won four of its last five matchups and pushed the Boise State Broncos to their limit in Week 12.

Here are our top picks for the Wyoming-Fresno State clash in Week 13 (odds via FanDuel Sportsbook and PointsBet; pick confidence is based on a 1-to-5-star scale).

Check out all of our top college football picks for Week 13!

Wyoming vs. Fresno State Odds

Wyoming vs. Fresno State Picks

Wyoming vs. Fresno State ATS Pick

Wyoming +15 (-110) ★★★★

Wyoming has been an underdog of 14-plus points four times in 2022, covering on three occasions. The Cowboys even won as 16.5-point underdogs against Air Force.

The Bulldogs have covered the last two times they were 14-plus-point favorites. However, there's nothing for them to play for in Week 13 after already wrapping up the West Division of the Mountain West. This is a prime lookahead spot for them, and Wyoming is a really dangerous team.

Check out our top sites for Maryland sports betting.

Wyoming vs. Fresno State O/U Pick

Under 50.5 (-105) ★★★

The Over has hit in five consecutive Fresno State games. That includes two contests when the total was set above 60.

It’s been a different story when the Cowboys are on the field, with the Under cashing during their last four contests. The highest line during that span was 50.5.

Wyoming is giving up just 22.8 points per game, and the Cowboys haven't allowed a team to score more than 20 against them since Oct. 1. The Bulldogs have held three of their last five opponents to 14 or fewer points. 

Offensively, the Bulldogs have scored 30-plus points in five consecutive games. However, they haven't faced a defense as good as Wyoming’s unit in a long time.

Wyoming vs. Fresno State Prop Pick

Wyoming first half +7.5 (-110) ★★★★

The Cowboys haven't faced a seven-plus point deficit at halftime since Oct. 1. They now hold a decided advantage over Fresno State in the first half, as the Bulldogs simply won’t be as invested in this game as they would have been earlier in the season. 

With the Bulldogs flat-footed, the Cowboys may even manage to sneak away with the first-half victory, just as they did against Boise State in Week 12. Their first-half moneyline is currently +370 through DraftKings.

Where to Bet on Wyoming vs. Fresno State Picks

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Wyoming-Fresno State picks made 11/22/2022 at 8:22 a.m. ET