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Israel Abanikanda of the Pittsburgh Panthers falls as he carries the ball in the second quarter of the game against the Georgia Tech Yellow Jackets at Acrisure Stadium on October 1, 2022 in Pittsburgh, Pennsylvania.
Israel Abanikanda of the Pittsburgh Panthers falls as he carries the ball in the second quarter of the game against the Georgia Tech Yellow Jackets at Acrisure Stadium on October 1, 2022 in Pittsburgh, Pennsylvania. Photo by Justin Berl/Getty Images via AFP.

The Pittsburgh Panthers host the Virginia Tech Hokies on Saturday on Week 6 in college football. Read on for our top Virginia Tech-Pittsburgh picks and predictions.

Pitt enters the Week 6 matchup off a 26-21 loss to Georgia Tech for which it closed as a 21.5-point favorite. That was the fourth time through five games that the Panthers failed to cover the spread.

VT is also 1-4 ATS for the season and failed to cover each of its last three times out. The Hokies have also lost back-to-back games outright, including a 41-10 loss to UNC last week.

Be sure to check out our college football best bets and all of our Week 6 picks.

Here are our Virginia Tech-Pittsburgh college football picks for Week 6 (odds via PointsBet and DraftKings Sportsbooks; pick confidence based on a 1-to-5-star scale).

Virginia Tech vs. Pittsburgh Game Info

Date: Saturday, October 8, 3:30 p.m. ET
TV: ACC Network
Location: Acrisure Stadium, Pittsburgh, PA
Weather: 56 degrees, 0% chance of precipitation, 15-mph winds

Virginia Tech vs. Pittsburgh Odds

Virginia Tech vs. Pittsburgh Odds Analysis

The spread opened at -15.5 in favor of Pitt and remains there as a consensus line. The Panthers have drawn 69% of the tickets but just 52% of the handle.

The Over/Under has dropped from 44 to 42.5 despite the Over drawing 64% of the tickets and 80% of the handle.

Virginia Tech vs. Pittsburgh Picks

  • Spread: Pittsburgh -14.5 (-107 via PointsBet) ★★
  • Over/Under: Over 41.5 (-107 via PointsBet) ★★★
  • Prop: Pittsburgh Over 27.5 points (-115 via PointsBet) ★★★★

Virginia Tech vs. Pittsburgh ATS Pick

Pittsburgh -14.5 (-107) ★★

If you’ve been backing either of these teams this season, then you’ve lost a lot. Both groups are just 1-4 against the spread, and neither one is playing very good football right now. However, it feels like oddsmakers are begging us to take the Hokies. 

Virginia Tech has been terrible over the last two weeks. The Hokies havee scored 10 points in each game while allowing a total of 74. The Panthers’ defense hasn’t been incredible by any means this season, but it is better than those which the Hokies have faced lately.

Don’t be fooled by the hook. Take the Panthers to cover this spread.

Virginia Tech vs. Pittsburgh O/U Pick

Over 41.5 (-107) ★★★

The Under cashed in all five Virginia Tech games this season. Some might argue that’s because of the Hokies’ strong defense, but it’s really because of their lifeless offense. In Week 1, they lost 20-17 to Old Dominion, then they held their next two opponents to a combined 17 points. The only problem is those two opponents were Boston College and Wofford.

The Over is 4-1 in Panthers’ games this year, and as the better team due for a bounce back, Pittsburgh may be able to hit this told by itself. If the Hokies are able to keep this close, it won’t be because their defense stopped the Panthers, it will be because the Panthers’ defense has problems stopping opponents from scoring.

Virginia Tech vs. Pittsburgh Prop Pick

Pittsburgh Over 27.5 points (-115) ★★★★

Pittsburgh scored four or more touchdowns in three of its five games this season. The only times it hasn't were in its 34-27 loss to Tennessee and in last week’s 26-21 loss to Georgia Tech. 

Last week, the final score wasn’t pretty, but QB Kedon Slovis put up pretty good numbers. He finished with 305 yards and three touchdowns, as Pitt outgained the Yellow Jackets 411-334 in total yards. 

The Panthers turned the ball over three times last week. That shouldn’t be a problem in Week 6, as Virginia Tech has caused only two turnovers since Week 1.

Where to Bet on Virginia Tech-Pittsburgh Picks

Virginia Tech-Pittsburgh picks made 10/5/2022 at 1:59 p.m. ET