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Zach Charbonnet of the UCLA Bruins runs with the ball at the Rose Bowl on Sept. 04, 2021 in Pasadena, California.
Zach Charbonnet of the UCLA Bruins runs with the ball at the Rose Bowl on Sept. 04, 2021 in Pasadena, California. Photo by Ronald Martinez/Getty Images via AFP.

The Colorado Buffaloes might be the worst team in the Power 5. How will the Buffs fare hosting the UCLA Bruins? Read on for our UCLA-Colorado picks.

Colorado mustered just four wins a season ago, and it’s likely the Buffaloes are even worse in 2022. Though UCLA struggled to put away South Alabama last week, the Bruins seem to have a more stable floor. Will that hold true in their conference opener?

Here are our top picks for UCLA-Colorado (odds via FanDuel Sportsbook, DraftKings Sportsbook, and BetMGM).

UCLA vs. Colorado Picks

  • UCLA -21 (-120 via DraftKings) ★★★
  • Under 57.5 (-110 via FanDuel, BetMGM) ★★★★
  • First-quarter spread: Colorado +7 (-105 via DraftKings) ★★★

UCLA vs. Colorado ATS Pick

UCLA -21 (-120) ★★★

Though the Bruins’ early performances against lowly competition makes a championship-caliber UCLA season unlikely, the Bruins are far-and-away superior to the Buffs.

UCLA is 3-0 with an average margin of victory of 22.3 points, which pales in comparison to 0-3 Colorado’s 32.7-point average margin of defeat. UCLA has gone 6-1 against the spread in its last seven road games. As a road favorite in that span, the Bruins are 3-1 ATS.

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UCLA vs. Colorado O/U Pick

Under 57.5 (-110) ★★★★

Two of Colorado’s three games this season cashed the Over but Colorado has scored just 30 points across those three contests. Its 10 points per game is tied for 124th in FBS.

UCLA averages 40.7 points per game, but has played one of the softest schedules in the nation. Though that doesn’t change this week, this will be the Bruins’ first road game and first conference game. In three matchups featuring UCLA as an away favorite last season, the Over went 1-2.

UCLA vs. Colorado Prop Pick

Colorado +7 first-quarter spread (-105) ★★★

Though UCLA scored well in its FBS wins, the Bruins left the opening quarter of both games trailing. They have scored a combined 13 points in those two first quarters.

Colorado likely won’t put up too many points—I like their team total Under 17.5 (-135) as well—but since UCLA has suffered woefully slow starts at home, it wouldn’t be surprising to see it happen in its first road contest. In their lone home game of the season, the Buffaloes led TCU 3-0 to end the first quarter.

Where to Bet on UCLA vs. Colorado Picks

Here are our top-rated sportsbooks:

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UCLA vs. Colorado picks made 9/22/2022 at 2:38 a.m. ET