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Drake Maye of the North Carolina Tar Heels rolls out against the Florida A&M Rattlers.
Drake Maye of the North Carolina Tar Heels rolls out against the Florida A&M Rattlers. Photo by Grant Halverson/Getty Images via AFP.

UNC has one of the nation’s most prolific offenses. Will the Notre Dame Fighting Irish know what hit them on Saturday? Read on for our Notre Dame-North Carolina picks.

North Carolina has come out of the right side of a couple of shootouts early in the season. Will the Tar Heels be able to dictate the tempo when a methodical Notre Dame group comes to town?

Here are our top picks for the college football Week 4 game between Notre Dame and North Carolina (odds via DraftKings Sportsbook and FanDuel Sportsbook; pick confidence based on a 1-to-5-star scale).  

Notre Dame vs. North Carolina Picks

  • Moneyline: North Carolina (-126 via FanDuel)
  • Over/Under: Under 55.5 (-110 via DraftKings)
  • Prop bet: Omarion Hampton to score 2-plus touchdowns (+300 via FanDuel)

Notre Dame vs. North Carolina ML Pick

North Carolina (-126) ★★★★

Notre Dame allows 351.7 yards per game (47th in FBS). That’s solid, but not enough to slow down a Tar Heels offense that loves to push the pace. North Carolina’s 23.3 seconds per play ranks as the 26th-fastest in FBS.

North Carolina also ranks in the top 50 in FBS in point-per-play margin. Quarterback Drake Maye is hitting on nearly 75% of his passes with an 11:1 touchdown to interception ratio.

UNC is 12-1 as a home favorite since 2020 and will enjoy the benefits of a raucous crowd this weekend.

Check out the latest comprehensive and most trusted Sportsbook Reviews by SBR.

Notre Dame vs. North Carolina O/U Pick

Under 55.5 (-110) ★★★

Each of North Carolina’s first three games has soared above 60 total points. However, none of Notre Dame’s games have gotten to 50; its offense (ranked 97th in seconds per play) will be dragged kicking and screaming through this game.

Even in the conceivable event that the Heels hit 30 points, Notre Dame’s season-high is 24. The Irish scored 10 points in their only previous road game.

Notre Dame vs. North Carolina Prop Pick

Hampton to score 2+ touchdowns (+300) ★★

Leading UNC rusher Omarian Hampton feels like a virtual lock to score (-210) on Saturday. So let’s make things interesting and project Hampton as the primary player to carry the Heels to victory.

Hampton has five scores on the season, scoring in every game and twice scoring two touchdowns. Notre Dame allows 167.7 yards per game on the ground (T-82nd in FBS) and has allowed a rushing score in every game this season.

Where to Bet on Notre Dame-North Carolina Picks

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Notre Dame-North Carolina picks made 9/23/2022 at 2:28 p.m. ET