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Quarterback Payton Thorne of the Michigan State Spartans throws the ball against the Akron Zips during the second quarter at Spartan Stadium.
Quarterback Payton Thorne of the Michigan State Spartans throws the ball against the Akron Zips during the second quarter at Spartan Stadium. Photo by Nic Antaya/Getty Images/AFP.

The Michigan State Spartans look to rebound from their loss to the Washington Huskies while the Minnesota Golden Gophers head out remain undefeated. Here are our Minnesota-Michigan State picks.

The Huskies upset the former No. 11 Spartans last week, but Michigan State heads home looking to ruin someone else’s perfect season as they host the 3-0 Golden Gophers.

Here are our Minnesota-Michigan State college football picks for Week 4 (odds via DraftKings Sportsbook and FanDuel Sportsbook; pick confidence based on a 1-to-5-star scale).

Minnesota vs. Michigan State Week 4 Game Info

  • Date: Saturday, Sept. 24, 3:30 p.m. ET
  • TV: Big Ten Network
  • Location: Spartan Stadium, East Lansing, MI
  • Weather: 63 degrees, 20% chance of precipitation, 8.7 mph winds

Minnesota vs. Michigan State Week 4 Odds Analysis

Opening as two-point favorites at, the Golden Gophers have moved slightly to 2.5-point favorites. They open as -145 favorites on DraftKings and -152 on FanDuel, while the Spartans are underdogs at home priced at +126 on FanDuel and +125 on DraftKings.

Minnesota vs. Michigan State Week 4 Picks

  • Spread: Michigan State +2.5 (+100 via DraftKings) ★★★
  • Over/Under: Over 51 points (-105 via DraftKings) ★★★★
  • Prop Pick: Michigan State +1.5 first half (-112 via Fanduel) ★★★

Minnesota vs. Michigan State ATS Pick

Michigan State +2.5 (+100) ★★★

The Spartans need a win and enjoy home field advantage. Even without star receiver Jayden Reed, Spartans quarterback Payton Thorne completed a career-high 30 passes, tallying 323 yards and three touchdowns despite the loss to the Huskies.

Minnesota relies on running back Mohamed Ibrahim, who averages 154.7 yards per game and has seven rushing touchdowns this season. By comparison, the Spartans have allowed just 89.7 rushing yards per game and only two rushing TDs.

Gophers QB Tanner Morgan has just four touchdowns and one interception in three games for Minnesota. With a Spartans rush defense that can shut down Ibrahim, they have a much easier chance to win by forcing the ball into Morgan’s hands. The Gophers are also missing leading receiver Chris Autman-Bell.

Minnesota vs. Michigan State O/U Pick 

Over 51 points (-105) ★★★★

The Spartans average 38.3 points per game this season and 115 total points, while the Gophers have scored 49.7 PPG and have hit 49 points or more on their own twice this season.

Minnesota and Michigan State both hit a combined Over of 51 points in two of their last three games this season. Michigan State scored 17 total touchdowns over three games while Minnesota tallied 20.

Minnesota vs. Michigan State Prop Pick

Michigan State +1.5 first half (-112) ★★★

In both of their previous 2022 home games, the Spartans led by at least 18 points going into the half. The Golden Gophers are yet to play on the road this year, but also led at halftime by double digits in each of their previous two home matchups this season.

While the Gophers dominated in their last three games, the Spartans have won five straight contests in this series. Minnesota’s last road win at Michigan State was in 2006. While Ibrahim has a 12 straight game streak with 100-plus rushing yards, the Spartans have not allowed a 100-yard rusher in their last 16 games.

Michigan State’s defense will be the toughest Ibrahim has seen yet, and without a reliable passer under center and missing their star wideout, the Gophers won’t have the tools to keep up with the Spartans in East Lansing, giving the home team the edge.

Where to Bet on Minnesota vs. Michigan State Picks

Here are our top-rated sportsbooks:

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Minnesota-Michigan State picks made 9/22/2022 at 3:25 p.m. ET