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Ben Bryant of the Cincinnati Bearcats throws a pass in the first quarter against the Miami (OH) RedHawks at Paycor Stadium.
Ben Bryant of the Cincinnati Bearcats throws a pass in the first quarter against the Miami (OH) RedHawks at Paycor Stadium. Photo by Dylan Buell/Getty Images via AFP.

The Cincinnati Bearcats are putting a 28-game home winning streak on the line as they host the 3-0 Indiana Hoosiers. Here are our insights for Indiana-Cincinnati picks.

Cincinnati got the 38-24 win when it met up with Indiana last September, but this time the Hoosiers are coming in undefeated at 3-0 and looking for revenge.

Here are our top picks for Indiana-Cincinnati (odds via DraftKings Sportsbook; pick confidence based on a 1-to-5-star scale).

Indiana vs. Cincinnati Picks

Indiana vs. Cincinnati ATS Pick

Cincinnati -17 (-110) ★★★★

The Bearcats have a 28-game home winning streak, and the Hoosiers are 0-9 straight up in their last nine games as underdogs. Cincinnati has lost one game, falling to No. 10 Arkansas by a 31-24 count to start the season.

Cincinnati won the last head-to-head meeting last year, and while the Hoosiers are bringing in a passing offense averaging 297.0 yards per game, Bearcats quarterback Ben Bryant tossed for 337 yards and two touchdowns as the Bearcats scored 31 unanswered points to beat Miami (Ohio) by 21 last week.

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Indiana vs. Cincinnati O/U Pick

Over 57.5 (-110) ★★★★

Indiana scored 33 points or more in each of its last two games while Cincinnati has scored 125 points over its first three games of the season. The last meeting between the two teams totaled 62, easily topping the betting line of 50.

The Hoosiers have scored 10 total offensive touchdowns this season with three players scoring at least twice. Meanwhile, the Bearcats have tallied 15 touchdowns and 1,441 yards of total offense. Cincinnati has hit the 55 combined point mark twice this season, and Indiana’s offense is much stronger than Miami (OH).

Indiana vs. Cincinnati Prop Pick

Cincinnati to win by 13-18 (+370) ★★★

The Bearcats won last year's encounter with the Hoosiers by 14 points and have won their last two games by margins of 14 points or more. The Hoosiers have escaped two of their three games this season by only three points.

Indiana is allowing 24 points and 445.3 yards per game from their opponents. Cincinnati is averaging just 19.3 points against – with 31 points coming from Arkansas in Week 1 - and allowing only 294.3 yards of offense per game.

While this winning margin prop matches the exact minimum amount Cincinnati would need to win by in order to cover the spread, the +370 payout is a quality hedge on the ATS pick.

Where to Bet on Indiana vs. Cincinnati Picks

Here are our top-rated sportsbooks:

FanDuel Sportsbook
Caesars Sportsbook
DraftKings Sportsbook
PointsBet
BetMGM

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Indiana-Cincinnati picks made 9/21/2022 at 4:23 p.m. ET