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Eriq Gilyard #13 of the Kansas Jayhawks is congratulated by Zion DeBose #35 and Shaad Dabney #16 after intercepting a pass against the Tennessee Tech Golden Eagles in the second half at David Booth Kansas Memorial Stadium on Sept. 2.
Eriq Gilyard #13 of the Kansas Jayhawks is congratulated by Zion DeBose #35 and Shaad Dabney #16 after intercepting a pass against the Tennessee Tech Golden Eagles in the second half at David Booth Kansas Memorial Stadium on Sept. 2. Photo by Ed Zurga / Getty Images via AFP

Two surprising 3-0 programs meet in Week 4 when Duke visits Kansas. Let's examine the matchup in Duke-Kansas picks.

The Kansas Jayhawks are coming off a 48-30 road win over Houston, while the Duke Blue Devils won as 10.5-point road underdogs against Northwestern two weeks ago.

Here are our college football betting picks for the Week 4 matchup between Duke and Kansas (odds via DraftKings Sportsbook, PointsBet; pick confidence based on a 1-to-5-star scale).

Duke vs. Kansas Picks

Duke vs. Kansas Spread Pick

Kansas -7.5 (-110) ★★★★

The Blue Devils' win at Northwestern looks much less appealing now that the Wildcats lost to Southern Illinois. Meanwhile, the Jayhawks have compiled two impressive road victories, largely thanks to taking care of the ball.

Duke has forced seven turnovers this year. Yet, even if the Blue Devils are able to turn the Jayhawks over once or twice, their offense won’t be able to keep up. Duke getting the hook from oddsmakers isn’t enough to draw consideration, as the Jayhawks win this one running away.

Duke vs. Kansas O/U Pick

Over 66.5 (-105) ★★★

This number is really high, but the Jayhawks’ offense has been good enough to warrant it. They are averaging 53.0 points per game and now they are going up against a defense that just gave up 20 to North Carolina A&T. 

The Blue Devils have scored at least 30 in every game this season. They’re going to score against the Jayhawks, who have allowed 30 or more in two of their three games. Oddsmakers don’t seem confident that these two teams will consistently play in the 70s yet, but that is where this game is heading.

Duke vs. Kansas Prop Pick

Kansas to score 50+ points (+360) ★★

The Blue Devils lost eight straight games to end the 2021 season. During that stretch, they gave up 45 or more points six times, including 54 to Pittsburgh and 62 to Louisville.

A favorable schedule has allowed Duke to put up decent numbers in 2022. However, the Jayhawks have scored over 50 twice this season, and they very nearly did it at Houston.

The value of this play is incredible. If it doesn’t hit, it’s going to be very close.

Where to Bet on Duke vs. Kansas

Here are our top-rated sportsbooks:

FanDuel Sportsbook
Caesars Sportsbook
DraftKings Sportsbook
PointsBet
BetMGM

SEE ALSO: All picksodds, and sports betting news. Be sure to check out SportsbookReview.com’s community forums and betting tools.

Duke vs. Kansas picks made 9/21/2022 at 10:56 a.m. ET