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Quarterback Jayden de Laura of the Arizona Wildcats celebrates with Josh Donovan after scoring an 11-yard rushing touchdown against the Washington State Cougars.
Quarterback Jayden de Laura of the Arizona Wildcats celebrates with Josh Donovan after scoring an 11-yard rushing touchdown against the Washington State Cougars. Photo by Christian Petersen/Getty Images via AFP.

The Territorial Cup is on the line as Pac-12 rivals, the Arizona State Sun Devils and Arizona Wildcats, clash in Friday's regular-season finale in a game expected to feature plenty of scoring. Read on for our top Arizona State-Arizona college football picks and predictions.

Arizona hasn’t beaten rival Arizona State since 2016. With both sides sporting porous defenses, could this be the year the Wildcats end the losing streak in the Duel in the Desert?

Here are our top picks for the college football Week 13 game between Arizona State and Arizona (odds via DraftKings Sportsbook, FanDuel Sportsbook, and BetMGM; pick confidence based on a 1-to-5-star scale).

Check out all of our top college football picks for Week 13!

Arizona State vs. Arizona Odds

Arizona State vs. Arizona Picks

Arizona State vs. Arizona ATS Pick

Arizona -4 (-110) ★★★

The biggest advantage in this game is Arizona’s solid offense (29th in FBS in efficiency) against ASU’s 107th-ranked defensive efficiency. Arizona recently upset UCLA on the road one week after ASU fell to the Bruins by 14 at home.

Arizona State is 3-5 against the spread as an underdog. The line is Arizona -4 (-110) across the board, so shopping around may not score you a benefit on this wager.

Check out our top sites for Maryland sports betting.

Arizona State vs. Arizona O/U Pick

Over 65 (-110) ★★★★

A combined 25 points for the Sun Devils against two top-20 defenses in their last two games helps to keep this total reasonable for Over bettors. Arizona State should move the ball much more effectively against Arizona’s 119th-ranked defensive efficiency.

Arizona averages 30.1 points per game on the season overall and 34.4 poibts when facing defenses outside the top 25 in efficiency. These two teams have combined to allow 71.1 points per contest on the season.

The line at DraftKings and BetMGM is half a point lower than FanDuel at the same -110 odds.

Arizona State vs. Arizona Prop Pick

First half Over 30.5 (-120)  ★★★★

Nine of Arizona’s 11 games have featured 30-plus total points in the first half, with no first half falling below 27 points in a Wildcats game this season. Arizona State has allowed 19.6 points per first half against FBS opponents.

Avoid FanDuel for this prop, as the line of O/U 33 is significantly different than the rest of the betting market. BetMGM is the best place for this prop, offering Over 30.5 at -120 odds. DraftKings offers Over 30.5 at -125 odds.

Where to Bet on Arizona State-Arizona Picks

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Arizona State-Arizona picks made 11/21/2022 at 6:13 a.m. ET