I'm going with 2 home dogs that are unbeaten at home as I think their opponents are overrated.
Anderlecht +200
Anderlecht play host to Ajax. Ajax is, at best, a local champion. They've been unbale to transfer their league form to the Europa competition. Ajax's offense hasn't really clicked in this competition and one highly doubts that Ajax's defense can shutout the Anderlecht's offense.
Red Bull Salzburg +220 WIN
Red Bull play host to Villareal. If the Spanish league ended today, Villareal would be relegated. That's the brutal truth! Villareal should be more concerned with their league games than Europa games. They have a league game against Espanyol on Sunday, which is a must-win if they want themselves out of the relegation zone. After beating Lazio in their last Europa game, Red Bull will savor their chances of bullying another overrated favorite.