I was just thinking that the spreads of Catholic Universities could be inflated because Catholics are betting on them just to root for Catholic teams. That could explain for example why St. Johns and Villanova are/were favored (when they probably shouldn't).
Before you laugh at that, please realize that the Catholic church is the biggest organization in the world with over a billion members. If they're mostly making "homer" bets for their organization, that would inflate lines a lot.